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The Impact of Hypoxia on the Biochemical and Morphological Parameters of Blood in Rowers.

The Effects of Live High-train Low on EPO, VEGF, and Hematological Variables in Elite Rowers

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06264193
Acronym
IHOBMPBR
Enrollment
13
Registered
2024-02-16
Start date
2014-11-30
Completion date
2014-12-21
Last updated
2025-01-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypoxia

Keywords

hypoxia, rowers, exercise, EPO, athletes, LH-TL

Brief summary

The response to hypoxia is very individual and epending on many aspects, such as the type of training, duration, intensity, or hypoxic stimulus, hypoxia affects the athlete in various ways. The results of this study have shown that 18 days of the LH-TL method does not significantly increase the level of EPO and VEGF in rowers. However, reticulocytes, immature red blood cells, have shown significant differences after 18-d LH-TL between groups. Further research should be carried out to investigate an optimal hypoxic dose and time, which will raise EPO, VEGF, and morphology variables.

Detailed description

The Polish national rower team athletes, 13 males (ages 27,0±4,2 years), were randomly divided into two groups: 1) The hypoxic group (H) included 8 rowers participating in sports training and the LH-TL method, hypoxic rooms (FiO2=14.5%, corresponds to an altitude of 3000 meters). 2) The control group (C) presented 5 rowers participating only in sports training and living in normoxic rooms, at the same sports camp. Rowers were observed during the preparatory period. The hypoxic group lived and slept in hypoxic rooms, for at least 8-14 hours per day. During the camp, all rowers followed the same training schedule and diet.All participants' saturation and heart rate were measured daily, morning and evening, throughout the camp period. Venous blood samples were taken four times, at the beginning of the camp (Baseline), after 5 days, after 12 days, and after 18 days of the camp. Body composition parameters such as body mass index, body fat, and free fat mass were estimated using the bioelectrical impedance method of an analyzer Tanita BC 418 (Japan). Data analysis was performed using Statistica. The response to hypoxia is very individual. Depending on many aspects, such as the type of training, duration, intensity, or hypoxic stimulus, hypoxia affects the athlete in various ways. The results of this study have shown that the blood parameters did not increase significantly in the hypoxic group compared to the control group. However, reticulocytes, immature red blood cells, have shown significant differences after 18-d LH-TL between groups. Further research should be carried out to investigate an optimal hypoxic dose and time, which will raise EPO, VEGF, and morphology variables.

Interventions

OTHERhypoxia

The athletes were living in hypoxic rooms, and training was carried out on lowlands.

Sponsors

Poznan University of Physical Education
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE

Intervention model description

The hypoxic group included rowers participating in sports training and the LH-TL method, hypoxic rooms (FiO2=14.5%, corresponds to an altitude of 3000 meters). And the control group participating only in sports training and living in normoxic rooms, at the same sports camp.

Eligibility

Sex/Gender
MALE
Healthy volunteers
Yes

Inclusion criteria

* member of national rower's teams, and sports camp participant.

Exclusion criteria

* negative symptoms of hypoxia, and/or injury.

Design outcomes

Primary

MeasureTime frameDescription
Erythropoietin (EPO) mlU/mlAt the beginning of the camp (Baseline), after 5 days (T1), after 12 days (T2), and after 18 days (T3) of the camp.immunoenzymatic assay methods using diagnostic kits
vascular endothelial growth factor (VEGF) mlU/mlAt the beginning of the camp (Baseline), after 5 days (T1), after 12 days (T2), and after 18 days (T3) of the camp.immunoenzymatic assay methods using diagnostic kits

Secondary

MeasureTime frameDescription
hemoglobin (Hb)g/dLAt the beginning of the camp (Baseline), after 5 days (T1), after 12 days (T2), and after 18 days (T3) of the camp.A professional accredited laboratory company determined the Hb level (Poland, ISO 9001:2008).
hematocrit (Htc)%At the beginning of the camp (Baseline), after 5 days (T1), after 12 days (T2), and after 18 days (T3) of the camp.A professional accredited laboratory company determined the Htc level (Poland, ISO 9001:2008).
red blood cells (RBC)mln/mm3At the beginning of the camp (Baseline), after 5 days (T1), after 12 days (T2), and after 18 days (T3) of the camp.A professional accredited laboratory company determined the RBC level (Poland, ISO 9001:2008).
creatine kinase (CK) ng/mlAt the beginning of the camp (Baseline), after 5 days (T1), after 12 days (T2), and after 18 days (T3) of the camp.was determined using spectrophotometer analysis and diagnostic kits
reticulocytes (Ret)‰At the beginning of the camp (Baseline), after 5 days (T1), after 12 days (T2), and after 18 days (T3) of the camp.A professional accredited laboratory company determined the Ret level (Poland, ISO 9001:2008).
SpO2 - oxygen saturation (%)every day, morning and evening, while sports campwas measured using a pulse oximeter (Tech-Med, ISO: 13485).
bpm - beats per minute(%)every day, morning and evening, while sports campwas measured using a pulse oximeter (Tech-Med, ISO: 13485).
white blood cells (WBC)10 3/µLAt the beginning of the camp (Baseline), after 5 days (T1), after 12 days (T2), and after 18 days (T3) of the camp.A professional accredited laboratory company determined the WBC level (Poland, ISO 9001:2008).
Hs C-Reactive Protein (hsCRP) mg/LAt the beginning of the camp (Baseline), after 5 days (T1), after 12 days (T2), and after 18 days (T3) of the camp.was determined by immunoenzymatic assay methods using diagnostic kits

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: May 15, 2026