High-Intensity Interval Training, Metabolic Syndrome, Myocardial Dysfunction
Conditions
Brief summary
the effects of high-intensity interval training on myocardial function will be studied in a group of patients under medical treatment for the components of metabolic syndrome.
Detailed description
Objective: To analyze the effects of high-intensity interval training (HIIT) on myocardial function of metabolic syndrome patients. Methods and design. Randomized clinical trial with a control group. Project was developed in association with the regional general hospital. Pre and post-intervention evaluation after 16 weeks of training for the HIIT group. Subjects: Recruited using adverts published on public medical center boards. Up to 30 subjects per group (HIIT and CONTROL) will be recruited (at least 20% women) Measurements. Echocardiography: Global longitudinal strain (GLS), Mitral filling parameters, myocardial dimensions, and myocardial wall thickness. Cardiorespiratory fitness: Maximal oxygen consumption, Maximal power output, Maximal oxygen pulse. Clinical: Metabolic syndrome components and derived variables (e.g., triglycerides/high-density lipoprotein ratio) Body composition by anthropometric measurements and dual-energy X-ray absorptiometry.
Interventions
BEHAVIORALHigh-intensity interval training
supervised exercise conducted on stationary bikes after individualized intensity prescription.
Sponsors
Complejo Hospitalario de Toledo
University of Castilla-La Mancha
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Masking description
Echocardiography evaluators will be masked about participant allocation.
Intervention model description
Randomized clinical trial with control group
Eligibility
Sex/Gender
ALL
Age
30 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Clinical diagnosis of metabolic syndrome. * Capacity to exercise on a stationary bike * Inhabitant of the province of Toledo
Exclusion criteria
* Untreated cardiovascular disease with hemodynamic instability * Untreated respiratory disease, symptomatic. * Untreated metabolic disease. * Untreated renal disease requiring dialysis. * Contraindications for high-intensity exercise training
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in global longitudinal strain | up to 16 weeks | response to myocardial strain after intervention. Assessed by echocardiography, measured as a percentage |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| changes in metabolic syndrome z-score | up to 16 weeks | Adimensional variable used to assess in a unified score, the changes in the components of metabolic syndrome. The z-score is based on the cut-off points ot the components(fasting serum concentrations of glucose, triglycerides, and high density lipoprotein, all measured in mg/DL), waist circumference measured in cm, systolic and diastolic blood pressure measured in mm Hg), and the variance of each variable among participants assessed by the standard deviation. |
| changes in visceral fat | up to 16 weeks | changes in visceral fat after intervention, assessed by dual-energy x-ray absortiometry. Measured in kg. |
| changes in cardiorespiratory fitness | up to 16 weeks | changes in maximal oxygen consumption measured in litres/min, all assessed by a cardiopulmonary exercise test in cycle-ergometer with breath by breath gas analysis. |
| changes in early diastolic mitral annulus velocity (e' wave) | up to 16 weeks | changes in early diastolic mitral annulus velocity (e' wave), assessed by echocardiography. Measured in m/seg. |
| changes in estimated left ventricle filling pressures (E/e') | up to 16 weeks | changes in estimated left ventricle filling pressures by E/e' ratio (Peak E-wave velocity divided by the peak e' velocity) obtained by echocardiography, being E and e' measured in m/seg. |
| changes in left ventricle passive filling (E wave) | up to 16 weeks | changes in early diastolic mitral inflow velocity (E wave), assessed by echocardiography. Measured in m/seg. |
Countries
Spain
Outcome results
None listed