Anorexia Nervosa
Conditions
Keywords
Biomarkers, Liver fibrosis, Liver steatosis, Anorexia nervosa, Enteral refeeding
Brief summary
The main goal of the BIocoLlection in Anorexia Nervosa-liver damage evaluation BILAN study the blood biomarkers associated with liver cytolysis.
Detailed description
Study of the association between blood biomarkers and the presence of hepatic cytolysis, defined by AST and/or ALT above normal.
Interventions
OTHERPatients with Anorexia Nervosa
Patients with Anorexia Nervosa hospitalized for malnutrition
Sponsors
Nantes University Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
15 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
: * Patient over 15 years old * Diagnosis of Restricted Eating Disorders including Anorexia Nervosa according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) * Admission to Nantes University Hospital.
Exclusion criteria
: * Chronic active viral hepatitis * Hemochromatosis * Other genetic, autoimmune. * Treatment with a drug known to induce fatty liver disease (amiodarone, carbamazepine, tamoxifen, valproate, clozapine, anti-retrovirals) unless the dose has been stable for ≥ 3 months * Excessive alcohol consumption (≥ 30 grams per day in men, ≥ 20 grams per day in women) * Pregnant, parturient or breast-feeding women, persons deprived of liberty, adults under legal protection or unable to express their consent, persons not affiliated or not beneficiaries of a social security scheme, persons under guardianship or curators
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Identification of new blood biomarkers and hepatic cytolysis | Two years | Identify changes in concentration of new blood biomarkers in patients suffering from hepatic cytolysis, defined by aspartate transaminases (AST) and/or alanine transaminases (ALT) above normal values, compared to those with normal enzyme levels. |
Countries
France
Outcome results
None listed