Antibiotic Resistant Strain, Transmission, Close-Contact
Conditions
Keywords
antibiotic resistant transmission, transmission between dog and human
Brief summary
Humans in contact with animals such as dog owners, may be at risk of antimicrobial resistance (AMR) acquisition. This is the central issue to be investigated in DYASPEO
Detailed description
Antimicrobial resistance (AMR) is a global and multifaceted public health problem. Advanced knowledge on AMR has demonstrated that it not only affects humans but is also widely distributed across animals and the environment. A major cause of the AMR burden refers to the capability of AMR to transmit within and between individuals, including between humans and animals. Leading examples of internationally distributed AMR bacteria are Enterobacterial disseminating resistances to extended-spectrum cephalosporins (ESC-E) and carbapenems (CP-E). Yet, the magnitude and pathways of their cross-sectorial transfers are poorly understood. There is a great concern that humans in contact with animals be at risk of ESC-E/CP-E acquisition. Whereas an increase in ESC-E carriage in farmers in contact with their food-producing animals was reported, AMR transmission to humans through direct contacts with companion animals has been much less studied. Owing the close relationships between pets and owners, and the fact that 50% of households host a dog or a cat in France, the hypothesis of pet ownership being a risk for humans to acquire ESC-E/CP-E appears strongly relevant. The DYASPEO project will investigate this question through a combination of several approaches from field to laboratory studies, and including epidemiology, ecology, molecular and population genomics, studies on intestinal microbiota, modelling and social sciences. We hypothesize that the interface between humans and companion animals plays a significant role in the transfer of ESC-E/CP-E. This hypothesis is corroborated (i) by recent data in France showing that antibiotic exposure of companion animals is still increasing contrary to all other animal host (e.g. food-producing animals) and (ii) by a recent study from the consortium demonstrating a high AMR prevalence in dogs getting back home after hospitalization.
Interventions
OTHERhuman faecal collection
collecting stools 6 times over a 90 days period and complete a questionnaire at the same times: D1, D7, D15, D30, D60 and D90
OTHERancillary study
interviews and/or ethnographic observations for 50 volunteers
Sponsors
Assistance Publique - Hôpitaux de Paris
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Adult or child planning to live in the same household as his/her dog during the three months following inclusion. * Planning to live in the same habitat in the next three months following inclusion (except for holidays). * Written consent of all adults and of at least one of the two parents for minors under parental authority. A different information note will be elaborated for each age category (6-10 yr-old, 10-15 yr-old and 16-18 yr-old). * Owning a dog recorded for a surgery at the National Veterinary School
Exclusion criteria
* Lack of signed informed consent * Subject in alternating custody * Subject under legal protection (guardianship) * Subject deprived of liberty under judicial constraint * Subject undergoing psychiatric care * Lack of affiliation to a social security scheme * Volunteers who do not speak/write French
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| generation of a list of priorities for future prevention and control strategies to mitigate antimicrobial resistance (AMR) transmission between companion animals and humans | over the 90 days follow up | mathematical models combining all the data (epidemiological, bacteriological, genomic, sociological) gathered in the project |
Secondary
| Measure | Time frame |
|---|---|
| A list in nature of changes in dog microbiota | over the 90 days follow up |
| A list in magnitude of changes in dog microbiota | over the 90 days follow up |
| A list in nature of changes in housekeepers microbiota | over the 90 days follow up |
| Rates of AMR acquisitions in one or several housekeepers | over the 90 days follow up |
| explore unknown parameters of AMR colonization in dogs under various antibiotic exposures | over the 90 days follow up |
| the generation of a list of sociological factors and potential at-risk practices relevant in the transmission of AMR from dogs to housekeepers | during semi-directive interviews and/or observational periods |
| A list in magnitude of changes in housekeepers microbiota | over the 90 days follow up |
Countries
France
Contacts
Primary ContactJean-Yves Madec, PHD
Outcome results
None listed