Diagnostic Value of Sentinel Node Biopsy Guided by Magnetic Probe
Conditions
Brief summary
Sentinel node biopsy has been shown to be a viable alternative to elective neck dissection in the early stages of squamous cell oral carcinoma. The aim of this study was to describe the magnetic localization of sentinel nodes (SN) after peritumoral injection of superparamagnetic iron oxide (SPIO) for treating this type of tumor and to analyze the technique's diagnostic performance in 23 patients. The technique located SNs (with minimal complication) in 95.6 % (22/23) of the patients. Three relapses occurred, one in a patient who had shown negative in magnetic SN location and elective neck dissection. The diagnostic performance of magnetic localization achieved a sensitivity and negative predictive value of 0.80 y 0.94, respectively. Magnetic localization of SNs has been shown to be a reproducible technique that may offer a viable alternative to the conventional technique.
Interventions
PROCEDURESentinel node biopsy guided by magnetic probe
Sentinel nodes exeresis guided by magnetic probe after injection submucosally and peritumorally of super-para-magnetic contrast. Standard neck dissection (levels I-II) were carry out after sentinel node biopsy
Sponsors
Hospital Donostia
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
29 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Oral squamous cell carcinoma T1-T2, cN0. * Absence of alterations to iron metabolism.
Exclusion criteria
* Previous neck surgery. * Treatment with iron chelators. * Pregnant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The diagnostic performance of SNB was analyzed in terms of sensitivity (S), specificity (Sp), negative and positive predictive value (NPV and PPV). | Six years |
Countries
Spain
Contacts
Primary ContactJosué Hernando, PhD, DDS
Outcome results
None listed