Wound Heal
Conditions
Brief summary
The goal of this observational study is to evaluate the post-extraction hard and soft tissue dimension changes in patients requiring consecutive extractions and unassisted socket healing in the anterior maxilla. The main questions it aims to answer are: * Is significant alveolar ridge resorption observed at center sites after consecutive extractions * Is significant alveolar ridge resorption observed at the interalveolar septum after consecutive extractions, are different extraction sites associated with significantly different bone resorption * Is a thick or thin wall phenotype associated with the amount of bone resorption * Is soft tissue thickness change associated with the corresponding location (extraction site or interalveolar septum) and post-extraction thickness of the bone * Is the interdental papilla height significantly affected after extractions. Participants will undergo consecutive (two) extractions and will be evaluated after subsequent unassisted socket healing for 8 weeks.
Interventions
None listed
Sponsors
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* 18+ years old * Require consecutive (two) teeth replacement in the anterior maxilla * Signed informed consent * No significant medical conditions * Patients with healthy periodontal conditions or previously treated to controlled and stable conditions
Exclusion criteria
* General medical (American Society of Anesthesiologists, ASA, class III or IV) and/or psychiatric contraindications * Pregnancy or nursing * Any interfering medication such as steroid therapy or bisphosphonate therapy * Uncontrolled diabetes * Autoimmune diseases or inflammatory diseases affecting the intraoral tissues * Radiation therapy to head or neck region
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Bone level change from baseline | Baseline and at 8 weeks | Measured in millimeters using segmented surface model superimpositions. Changes in bone loss between baseline and an 8 week healing period using CBCT. From the Digital Imaging and Communications in Medicine (DICOM) files two surface mesh models were generated, which were superimposed and the changes were subsequently analyzed. |
| Soft tissue change from baseline | Baseline and at 8 weeks | Changes in soft tissue loss at baseline and 8 weeks were analyzed using digital dental impressions acquired from intraoral scans, which were superimposed and the changes were analyzed. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between baseline facial bone thickness and dimensional soft tissue alterations during healing at the interalveolar septum. | Baseline and at 8 weeks | To measure correlation, the Spearman Rank Correlation Coefficient was calculated. Nonparametric models for longitudinal data were applied to analyze the impact of bone wall phenotype and healing period upon dimensional alterations. |
Contacts
Primary ContactXinbo Yu
Outcome results
None listed