Intralesional Acyclovir Versus Cryotherapy in the Treatment of Plantar Warts. A Randomized Controlled Trial.

Status

Recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06261684

Enrollment

Registered

2024-02-15

Start date

2023-10-01

Completion date

2024-10-01

Last updated

2024-02-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Plantar Wart

Brief summary

The goal of this prospective randomized controlled study is to study the safety and efficacy of intralesional acyclovir compared to cryotherapy in plantar warts. The main questions needed to be answered are: 1. Is Intralesional acyclovir safe for plantar warts? 2. Is Intralesional acyclovir more efficient in treating plantar warts compared to cryotherapy?

Interventions

DRUGIntralesional Acyclovir

Intralesional Acyclovir in plantar warts

DEVICECryotherapy

Cryotherapy of plantar warts

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Patients aged 18 years or older, of both genders, with plantar warts

Exclusion criteria

* Patients on systemic treatment for warts eg. Acitretin, Acyclovir * Hypersensitivity to Acyclovir * Previous treatment to the same wart during the last 3 months * Immunocompromised patients (as HIV, steroid intake, uncontrolled diabetes, etc.) * Pregnant and breastfeeding females * Cognitively impaired patients

Design outcomes

Primary

Measure	Time frame	Description
Cure rate	10 weeks (5 sessions max)	Number of patients healed after completion of the sessions
Recurrence rate	24 weeks	Number of patients had recurred plantar warts after receiving the treatment
Patient satisfaction score	10 weeks	Patient satisfaction questionnaire score

Secondary

Measure	Time frame	Description
Correlation of treatment with number of ipsilateral warts	10 weeks	Number of warts increased, decreased or stationary
Correlation of treatment with size of the wart	10 weeks	Percentage of successful treatment compared to the size of the wart
Correlation of treatment with age	10 weeks	Percentage of patients successfully treated in each age group (Young 18-32 years; Middle age 33-46, Old age 47-60
Correlation of treatment with gender	10 weeks	Percentage of successfully treated male to female patients

Countries

Egypt

Contacts

Primary ContactBasant Helal, MRCP

basant_helal@hotmail.com+201144166922

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026