Obstructive Sleep Apnea
Conditions
Brief summary
The purpose of this study is to investigate potential sex differences in neurocirculatory control of blood pressure in patients with untreated obstructive sleep apnea (OSA).
Interventions
None listed
Sponsors
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Mayo Clinic
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Inclusion criteria
* 20-70 years of age
Exclusion criteria
* Coronary artery disease * Heart failure * Pregnancy * COPD * Diabetes * CKD * Sleep disorders other than OSA * Shift workers * Individuals who typically go to sleep after midnight * Individuals who traveled across ≥2 time zones within one week of study visits * BMI ≥40.0kg/m2 * Use of nicotine-containing products within the two years preceding study visits * Use of allopurinol, proton pump inhibitors, or other medications/supplements which interfere with outcome measures
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood pressure | Baseline | Measured in millimeters of mercury (mmHg). |
| Endothelial function | Baseline | Ultrasound assessment of flow-mediated vasodilation of the brachial artery. Brachial artery diameter and blood velocity will be measured after deflation to measure endothelial function. |
| Arterial stiffness | Baseline | Measured by applanation tonometry reported as aortic pulse wave velocity (m/sec) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Sympathetic nerve burst frequency | Baseline | Measured by Microneurography reported as number of nerve bursts per minute (burst/min) |
| Sympathetic nerve burst incidence | Baseline | Measured by Microneurography reported as number of nerve burst per 100 heart beats (burst/100 heart beats) |
| Sympathetic nerve burst amplitude (AU) | Baseline | Measured by Microneurography reported in arbitrary units (AU) |
| Total muscle sympathetic nerve activity (MSNA) | Baseline | Measured by Microneurography reported burst arbitrary units per minute (AU/min) |
Other
| Measure | Time frame | Description |
|---|---|---|
| Cerebral autoregulation | Baseline | Measured by transcranial doppler ultrasound (cm/sec). |
| Sympathetic action potential conduction latency of each cluster | Baseline | Measured by Microneurography reported as conduction latency of each cluster (reflecting synaptic delays and verifying larger amplitude clusters as new populations). |
| Sympathetic action potential clusters per burst | Baseline | Measured by Microneurography reported as clusters per burst (reflecting recruitment of latent subpopulations). |
| Sympathetic action potentials per burst | Baseline | Measured by Microneurography reported as action potentials per burst (reflecting firing rate). |
| Immune function | Baseline | Immune function will be measured as percent of parent cell population. |
| Urinary Extracellular Vesicle Presence and Content | Baseline | Number of extracellular vesicles present in a 24 hour urine collection and the contents being carried by those vesicles. |
| Plasma Extracellular Vesicle Presence and Content | Baseline | Number of extracellular vesicles present in blood plasma sample and the contents being carried by those vesicles. |
Countries
United States
Contacts
Primary ContactJoshua Bock, PhD
Backup ContactIan Greenlund, PhD
Outcome results
None listed