Postoperative Pain, Acute
Conditions
Brief summary
This study is a randomized, controlled trial. A total of 48 patients will be randomized to receive sufentanil or remifentanil during robot-assisted nephrectomy surgery.
Interventions
DRUGSufentanil
Induction: sufentanil TCI 0.3 ng/ml Maintenance: sufentanil TCI 0.05-0.5 ng/ml
DRUGRemifentanil
Induction: remifentanil TCI 3 ng/ml Maintenance: remifentanil TCI 0.5-5 ng/ml
Sponsors
Seoul National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients who undergo elective robot-assisted nephrectomy surgery * American Society of Anesthesiologists grade 1,2,3 * Age \> 18 years old
Exclusion criteria
* Refuse to participate to the study * Allergic history of opioid * chronic pain * opioid user before surgery * MAO inhibitor user * Severe respiratory insufficiency
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| opioid consumption | During post-anesthesia care unit(PACU) stay, until 1 hour |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Richmond Agitation-Sedation scale | During post-anesthesia care unit(PACU) stay, until 1 hour | (+4), Combative, Overtly combative or violent; immediate danger to staff (+3), Very agitated, Pulls on or removes tube(s) or catheter(s) or has aggressive behavior toward staff (+2), Agitated, Frequent nonpurposeful movement or patient-ventilator dyssynchrony (+1), Restless, Anxious or apprehensive but movements not aggressive or vigorous 0, Alert and calm, Spontaneously pays attention to caregiver (-1), Drowsy, Not fully alert, but has sustained (more than 10 seconds) awakening, with eye contact, to voice (-2), Light sedation, Briefly (less than 10 seconds) awakens with eye contact to voice (-3), Moderate sedation, Any movement (but no eye contact) to voice (-4), Deep sedation, No response to voice, but any movement to physical stimulation (-5), Unarousable, No response to voice or physical stimulation |
| Incidence of postoperative nausea and vomiting | During post-anesthesia care unit(PACU) stay, until 1 hour | — |
| Number of patients who administered antiemetics | During post-anesthesia care unit(PACU) stay, until 1 hour | ramosetron will be administered as antiemetics |
| Pain score | immediately after surgery, 15minutes, 30minutes, 60minutes after surgery | Numeric rating scale (0=none, 10=extremely pain) |
Countries
South Korea
Contacts
Primary ContactChang-Hoon Koo
Outcome results
None listed