Sepsis
Conditions
Brief summary
The current project was designed to examine the effects of BCAA metabolic dysfunction on cardiac function in septic patients.
Detailed description
Patients with sepsis and with/without type 2 diabetes will be included. Patients prospectively collected the following indicators in the intensive care unit: 1. myocardial injury-related biomarkers: troponin T and B natriuretic peptide levels; 2. cardiac structure-related indicators: the size of the left and right ventricle, left ventricular ejection fraction, etc.3. septic cardiomyopathy incidence: Troponin T\>0.01ng/ml is the standard for the diagnosis of septic cardiomyopathy. Additionally, the investigators will collect the peripheral blood at preoperative, day 1, day 3, and day 5 after surgery. Peripheral blood plasma and PBMCs were separated by differential centrifugation: the concentration of BCAAs in serum and PBMCs; the expression of PBMCs BCAAs metabolic enzymes BCAT 1, BCKDH, and PP 2 Cm by WB; and the levels of AST, ALT, LDH, CK, and CK-MB
Interventions
OTHEREffect of BCAAs metabolic dysfunction on cardiac function in sepsis
Effect of BCAAs metabolic dysfunction on cardiac function in sepsis
Sponsors
West China Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
\- patients diagnosed with sepsis with or without type 2 diabetes
Exclusion criteria
\- patients with immunodeficient diseases patients who accept glucocorticoid or immunosuppressant patients with an age younger than 18 years patients who cannot provide informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The incidence of Sepsis induced cardiomyopathy | up to 7 days post-ICU admission, or at hospital discharge, whichever comes first | Diagnostic criteria for Sepsis induced cardiomyopathy, TroponinT \> 0.01 ng/ml |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Plasma levels of TroponinT | up to 7 days post-ICU admission, or at hospital discharge, whichever comes first | If multiple measurements is available during the first 7 days, the mean measurement will be used for analysis. |
| Plasma levels of type B natriuretic peptide | up to 7 days post-ICU admission, or at hospital discharge, whichever comes first | If multiple measurements is available during the first 7 days, the mean measurement will be used for analysis. |
| ejection fraction | up to 7 days post-ICU admission, or at hospital discharge, whichever comes first | If multiple measurements is available during the first 7 day, the mean measurement will be used for analysis. |
| Left ventricular and right ventricular size | up to 7 days post-ICU admission, or at hospital discharge, whichever comes first | If multiple measurements is available during the first 7 day, the mean measurement will be used for analysis. |
Contacts
Primary ContactChunling Jiang, PhD
Outcome results
None listed