Lymphangioma, Lymphatic Malformation
Conditions
Keywords
Lymphatic Malformation, Abdominal site, Preoperative complications, Resection, Mesentery, Acute abdomen
Brief summary
The primary purpose of this study is to retrospectively identify the clinical characteristics of abdominal lymphatic malformations (ALMs) in our single center in China. The second objective of this study is to retrospectively compare the epidemiological features, clinical presentations, cyst properties, surgical treatments, and risk factors for preoperative complications of ALMs between paediatric participants and adult participants.
Detailed description
Lymphatic malformations (LMs) are vascular anomalies that arise from abnormal embryonic development of the lymphatic system and can present as dilated lymphatic channels or cysts lined by lymphatic endothelial cells. Abdominal lymphatic malformations (ALMs) are rare entities that account for fewer than 10% of LMs and may occur not only in the tissues or organs in the abdominal cavity, such as the mesentery, spleen and pancreas but also in the retroperitoneal space. ALMs can manifest as an infection, chronic abdominal discomfort, acute abdomen, or fatal disease.
Interventions
OTHERCompare the epidemiological characteristics, clinical presentations, surgical treatments and risk factors for preoperative complications of ALMs between paediatric and adult participants.
Compare the epidemiological characteristics, clinical presentations, surgical treatments and risk factors for preoperative complications of ALMs between paediatric and adult participants.
Sponsors
West China Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Inclusion criteria
* The investigators enrolled participants who were pathologically diagnosed with lymphangioma or lymphatic malformations in the abdominal cavity (i.e., abdominal lymphatic malformations) from January 2009 to December 2022 at our institution.
Exclusion criteria
* The investigators excluded participants without a pathological diagnosis of abdominal lymphatic malformations through resection specimens and those with pathological confirmation of other diseases, as well as patients with complex lymphatic anomalies.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The preoperative complications of abdominal lymphatic malformations in participants | From 2009.1 to 2022.12 | Preoperative complications included intestinal volvulus, haemorrhage, infection, rupture and compression. |
| The location of abdominal lymphatic malformations in participants | From 2009.1 to 2022.12 | Location included mesentery, retroperitoneum, omentum, spleen, etc. |
| The morphologic subtypes of abdominal lymphatic malformations in participants | From 2009.1 to 2022.12 | Morphologic subtypes included macrocystic, microcystic and mixed type. |
| The presentations at diagnosis of abdominal lymphatic malformations in participants | From 2009.1 to 2022.12 | Presentations at diagnosis included chronic pain, acute abdominal disease and incidental health checkup. |
| The largest diameter of abdominal lymphatic malformations in participants | From 2009.1 to 2022.12 | Largest diameter in centimeters was mainly measured by intraoperative detections. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The incidence of abdominal lymphatic malformations in paediatric and adult group | From 2009.1 to 2022.12 | Incidence of abdominal lymphatic malformations in paediatric and adult group was retrospectively compared. |
| The number of female patients with abdominal lymphatic malformations in paediatric and adult group | From 2009.1 to 2022.12 | Number of female patients with abdominal lymphatic malformations in paediatric and adult group was retrospectively compared. |
| The rate of abdominal lymphatic malformations with acute abdomen in paediatric and adult group | From 2009.1 to 2022.12 | Rate of abdominal lymphatic malformations with acute abdomen in paediatric and adult group was retrospectively compared. |
| The rate of abdominal lymphatic malformations located in mesentery for paediatric and adult group | From 2009.1 to 2022.12 | Rate of abdominal lymphatic malformations located in mesentery for paediatric and adult group was retrospectively compared. |
| The risk factors of preoperative complications of abdominal lymphatic malformations for paediatric and adult group. | From 2009.1 to 2022.12 | Risk factors of preoperative complications of abdominal lymphatic malformations for paediatric and adult group was retrospectively compared. |
Countries
China
Outcome results
None listed