Ketogenic Diet
Conditions
Brief summary
This study was conducted on thirty children aged from12 months to 18 years newly diagnosed with drug resistant epilepsy and following up at Pediatric Nutrition and Neurology Outpatient Clinics assigned randomly into 2 groups, group1: patients who started ketogenic diet with L-carnitine and group2: patients who started ketogenic diet only.
Interventions
DIETARY_SUPPLEMENTL- Carnitine
L-carnitine was taken after feeds in the form of tablets or dissolved tablets in a dose of 50 mg/kg/day, with maximum dose of 2 g/day.
OTHERketogenic diet
ketogenic diet (KD) initiated under supervision of expert physician who considered patient's age, type of feeding, needs and preferences of the child and his/her family to select the type and initial ratio of KD therapy, KD ratio ranged from 1:1 to 4:1 of lipids to carbohydrates plus proteins in grams.
Sponsors
Ain Shams University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
12 Months to 18 Years
Healthy volunteers
No
Inclusion criteria
* All infants and children aged from 12 months to 18 years old newly diagnosed with drug resistant epilepsy and were assigned to start KD.
Exclusion criteria
* Patients with intolerance or non-compliance to ketogenic diet therapy. * Patients for epilepsy surgery or vagal nerve stimulation. * Children with history of previous abdominal operations. * Children with history of GI diseases affecting GI motility before starting KD. * Children with tube feeding or feeding gastrostomy or jejunostomy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Assessment the effect of L-carnitine supplementation on gastric emptying in children with drug resistant epilepsy (DRE) on ketogenic diet (KD). | At time of enrollment and 3 months of intervention. | Antral length measurement using abdominal ultrasonography. |
Countries
Egypt
Outcome results
None listed