Eye Diseases
Conditions
Keywords
biomarkers, limbic stem cell deficiency, dry syndrome, EYEPRIM
Brief summary
In order to develop innovative biomarkers for the diagnosis of two ocular surface pathologies, Dry Syndrome (DS) and Limbic Stem Cell Deficiency (LSCD), human cells from the ocular surface will be collected in order to test these biomarkers ex vivo.
Detailed description
To collect them, cytological fingerprints of the ocular surface are made using filter paper applied to the surface using a commercially available EC (European Conformity)-marked medical device, called EYEPRIM.
Interventions
DIAGNOSTIC_TESTEYEPRIM
Collection of conjunctival impressions using the EC(European Conformity )-marked EYEPRIM device . This device enables cells to be collected the superficial ocular surface cells by applying a membrane for few seconds to the ocular surface.
Sponsors
Laboratoire Biologie, Ingénierie et Imagerie de la Greffe de Cornée (BiiGC)
Centre Hospitalier Universitaire de Saint Etienne
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient affiliated or entitled to a social security scheme * Age 18 years or older * Presenting a Dry Syndrome, a limbic stem cell deficiency (clinical diagnosis) or another pathology (control). * Signature of Consent
Exclusion criteria
* Major blepharospasm making examination impossible * Pregnant women * Breastfeeding women * Protected Persons
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Ocular surface impression cytology collected from patients suffering from dry eye syndrome, limbal stem cell deficiency or other pathologies (control). | day one | Collection of cells from the ocular surface by performing a cytological imprint of the ocular surface |
Countries
France
Outcome results
None listed