Analgesia, Anesthesia, Thoracic
Conditions
Brief summary
Postoperative pain is a significant concern following video-assisted thoracoscopic surgery (VATS). Pain after thoracic surgery not only causes a strong stress reaction and adverse emotional experience but also affects postoperative rehabilitation. Hence, different analgesia techniques, including local anesthetic infiltration, intercostal nerve block, paravertebral block, and thoracic epidural anesthesia, have been described to attenuate the intensity of acute postoperative painparavertebral block (PVB) and Rhomboid intercostal block with sub-serratus plane block (RISS) are the two types of plane blocks used for postoperative analgesia after video-assisted thoracoscopic surgery (VATS). This prospective randomized controlled trial was performed to analyze the postoperative analgesic effects of ultra- sound-guided PVB and RISS block after video-assisted thoracoscopic surgery.
Interventions
PROCEDUREPARAVERTEBRAL BLOCK
Hemodynamic data (mean arterial pressure, heart rate, oxygen saturation) will be recorded for all patients every 30 minutes during the intraoperative period, along with the amount of opioids used throughout the surgery. A patient-controlled analgesia device (PCA) will be connected to each patient 15 minutes before awakening, prepared with a 1mg/ml morphine solution, with a bolus dose of 2 ml and a lockout period of 15 minutes
Hemodynamic data (mean arterial pressure, heart rate, oxygen saturation) will be recorded for all patients every 30 minutes during the intraoperative period, along with the amount of opioids used throughout the surgery. A patient-controlled analgesia device (PCA) will be connected to each patient 15 minutes before awakening, prepared with a 1mg/ml morphine solution, with a bolus dose of 2 ml and a lockout period of 15 minutes.
PROCEDUREPLACEBO
Hemodynamic data (mean arterial pressure, heart rate, oxygen saturation) will be recorded for all patients every 30 minutes during the intraoperative period, along with the amount of opioids used throughout the surgery. A patient-controlled analgesia device (PCA) will be connected to each patient 15 minutes before awakening, prepared with a 1mg/ml morphine solution, with a bolus dose of 2 ml and a lockout period of 15 minutes.
Sponsors
Uludag University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Planned for VATS * American Society of Anesthesiologists (ASA) class I and II * Patients aged between 18-80
Exclusion criteria
* Contraindications to local anesthetic allergy or bupivacaine * Known or suspected coagulopathy * Injection site infection * History of thoracic surgery * Severe neurological or psychiatric disorder * Severe cardiovascular disease * Liver failure * Renal failure (glomerular filtration rate \<15 ml/min/1.73 m2) * Chronic opioid use
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| VAS scores | up to 24 hours | The primary outcome of this study was to compare the analgesia of paravertebral block versus rhomboid intercostal and subserratus plane block in VATS surgery. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| morphine consumption | up to 24 hours | The secondary outcome measure in this study was 24-hour morphine consumption. |
| first analgesia requirement | up to 24 hours | Secondary outcome measures included time to first request for morphine |
| Side effects | up to 24 hours | Side effects associated with morphine consumption |
Countries
Turkey (Türkiye)
Contacts
Primary ContactSEDA CANSABUNCU
Outcome results
None listed