Acute Kidney Injury, Sepsis
Conditions
Keywords
Acute Kidney Injury, Blood Purification, Adsorptive membranes, Sepsis, Cytokines
Brief summary
It is an epidemiology study to explore outcomes in patients with acute kidney injury (AKI) and sepsis submitted to continuous renal replacement therapy (CRRT) with Oxiris™. Objectives: Describe the experience and outcomes in patients with sepsis and AKI treated receiving CRRT with the adsorption membrane filter Oxiris™
Detailed description
Study Background & Rationale: Acute kidney injury (AKI) is common in patients with sepsis, occurring in 5-50%. It happens in the context of a critical illness requiring intensive care. Fifteen percent require renal replacement therapy as supportive therapy until the kidneys recover. Membrane-coated filters, such as Oxiris™, promote high filtration clearance of uremic toxins, but additionally removal of inflammatory mediators and bacterial liposaccharide (LPS) . Even though this potential mechanism should be expected to benefit septic and AKI patients, results have not been uniform. The investigators´ group has been prescribing CRRT for AKI treatment for the last 20 years, having performed more than 20 thousand procedures. The investigators´ group experience with Oxiris™ filter in CRRT started in 2018. The objective of the study is to describe the clinical operational management of CRRT with this kind of filter and to explore patients' outcomes.
Interventions
DEVICEAdsorption membrane filter Oxiris™
Continuous Renal Replacement Therapy with the adsorption membrane filter Oxiris™
Sponsors
Baxter Healthcare Corporation
Nefro Consultoria de Doenças Renais Ltda
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
* Adults (\>18 years) * Diagnosis of AKI (KDIGO stage 3) * Diagnosis of sepsis of any cause
Exclusion criteria
* COVID19 diagnosis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mortality observed and estimated by predictive indexes | Through study completion, an average of 5 years | In-hospital mortality observed and estimated by the predictive index (SAPS III) during the hospitalization which developed AKI and need CRRT with Oxiris |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Management of hemodynamic drugs during CRRT | Through study completion, an average of 5 years | Daily dosage of hemodynamic active drugs (mg/day) during the hospitalization which developed AKI and need CRRT with Oxiris |
| Hemorrhagic complications during CRRT | Through study completion, an average of 5 years | Occurrence of hemorrhagic events during the hospitalization which developed AKI and need CRRT with Oxiris |
| CRRT circuit life-time | Through study completion, an average of 5 years | Days of CRRT circuit with Oxiris utilization, during the hospitalization which developed AKI and need CRRT with Oxiris |
| CRRT dependence | Through study completion, an average of 5 years | Time in days on CRRT need, during the hospitalization which developed AKI and need CRRT with Oxiris |
| Initial renal function recovery | Through study completion, an average of 5 years | Time in days to urinary debt \>1L/day, during the hospitalization which developed AKI and need CRRT with Oxiris |
| Length of hospital stay | Through study completion, an average of 5 years | Length of hospital stay in days of hospitalization which developed AKI and need CRRT with Oxiris |
| Renal function recovery in medium term | At 30 days after hospital admission in which participants developed AKI | Renal function by creatinine levels (mg/dl) at 30 days after hospital admission of the hospitalization which developed AKI and need CRRT with Oxiris |
| Renal function recovery at discharge | Through study completion, an average of 5 years | Renal function by creatinine levels (mg/dl) at discharge of the hospitalization which developed AKI and need CRRT with Oxiris |
| Dialysis dependence in long term | Through study completion, an average of 5 years | Dialysis dependence at discharge of the hospitalization which developed AKI and need CRRT with Oxiris |
Countries
Brazil
Outcome results
None listed