Stroke
Conditions
Brief summary
If there is a comparison group: Researchers will compare \[insert groups\] to see if \[insert effects\] The purpose of the clinical trial is to find a treatment for stroke patients with cognitive impairment, and the main questions it aims to answer are: * \[Search for effective treatments of cognitive impairment after stroke\] * \[Explore brain network features with functional near-infrared spectroscopy\] Participants will receive conventional treatment, tDCS treatment, or rTMS treatment, or tDCS-rTMS treatment. And then compare cognitive function and brain function.
Interventions
OTHERroutine treatment
Routine medical treatment, basic rehabilitation training and individualized cognitive training
tDCS&rTMS
Sponsors
The Second Affiliated Hospital of Dalian Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
30 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Meet the clinical diagnostic criteria of the Expert Consensus on the Management of Cognitive Impairment after Stroke in 2021; * 30-80 years old, right-handed, unilateral hemiplegia; * Verbal expression can cooperate with the completion of the evaluation, sustained attention time is longer than 5 minutes; * Simple Mental State Examination Scale (MMSE) score ≤26 points; MoCA scale score \< 26 points; Memory test (RMBT) score less than 21 points; * patients or their family agree to sign the informed consent; * The Ethics Committee approved the trial.
Exclusion criteria
* Memory dysfunction caused by other diseases, such as Alzheimer's disease, lewy body dementia, pituitary tumor surgery, hypothyroidism, etc.; * There are contraindications of rTMS and tDCS for untreated intracranial aneurysms, severe epilepsy, intracranial metal, etc. * Patients with severe visual, cognitive or speech impairment who cannot cooperate with treatment; * The condition is not stable; Or other serious physical diseases.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Concentration of brain's HbO by functional near-infrared spectroscopy | 2 weeks | fNIRS |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Score of The Frontal Assessment Battery | 2 weeks | FAB |
| Score of Attention assessment by the digit span task | 2 weeks | DST |
| Score of Mini-Mental State Examination | 2 weeks | MMSE |
Countries
China
Contacts
Primary ContactWuyao Pan
Backup ContactRen
Outcome results
None listed