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Comparative Analysis of Radiotherapeutic and Medical Procedures for the Prophylaxis of Heterotopic Ossifications

Comparative Analysis of Radiotherapeutic and Medical Procedures for the Prophylaxis of Heterotopic Ossifications in the Context of Total Hip Arthroplasty

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06251349
Acronym
CONFIDENTIAL
Enrollment
512
Registered
2024-02-09
Start date
2013-01-01
Completion date
2023-12-31
Last updated
2024-02-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heterotopic Ossification, Hip Arthropathy, Myositis Ossificans Traumatica, Thigh

Keywords

Heterotopic Ossification, Total Hip Arthroplasty, Irradiation Hip, Diclofenac, Prevention of HO, NSAID, Brooker Classification

Brief summary

Aim of this study is to proof the efficacy of in Jena established prophylaxis of new bone formation aside the skeleton with irradiation and compare it with the common literature. Furthermore we want to compare irradiation treatment with the alternative prophylaxis with analgetics from the NSAID type.

Detailed description

Aim of this retrospective analysis is to compare the incidence of heterotopic ossification one year after total hip arthroplasty with the at our location established concept of irradiation 24h preoperative and incidence in common literature. Furthermore the comparison between irradiated patients and patients treated with NSAIDs.

Interventions

RADIATIONRadiation

Single dose radiation with 7-8 Gy

DRUGDiclofenac

postoperative treatment with diclofenac to prevent HO

Sponsors

University of Jena
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

Patients with total hip arthroplasty performed at Eisenberg Patients with preoperative irradiation (24h pre-op) or postoperative diclofenac treatment Patients with x-ray images immediately (3-5 days postoperative) postoperative and at least 365 days postoperative

Exclusion criteria

Patients with missing follow up image

Design outcomes

Primary

MeasureTime frameDescription
Presence of heterotopic ossification (HO)at least 365 days postoperativeX-ray controlled HO diagnostics with the Brooker classification

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026