Colorectal Cancer
Conditions
Keywords
oxaliplatin, reflexology
Brief summary
The management of colorectal cancer often requires oxaliplatin-based chemotherapy, either as part of curative treatment plans or exclusively in palliative situations. Oxaliplatin therefore plays a key role in the management of colorectal cancer. In addition to its digestive and hematological toxicity, oxaliplatin frequently induces chronic, often limiting, sensitive peripheral neuropathy. Only early discontinuation of oxaliplatin can limit the risk of clinically limiting neurotoxicity (grade ≥ 3). In oncology, managing the side-effects of treatment is an essential objective of supportive care, and is open to a variety of complementary medicines, including reflexology. This technique, derived from traditional Chinese medicine, involves stimulating reflex points on the arch of the foot.
Detailed description
This first monocentric, prospective pilot study is designed to evaluate if the intervention is feasible in routine clinical practice for patients initiating bimonthly oxaliplatin chemotherapy for colorectal cancer. It will also provide initial estimates of the parameters needed to measure efficacy and impact on patient quality of life. Patients will receive a reflexology session with each cycle of chemotherapy, and will be assessed during all the treatment period.
Interventions
OTHERFoot reflexology
30 minutes reflexology session
Sponsors
University Hospital, Toulouse
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Intervention model description
All patients will receive a 30-minute reflexology session during each Oxaliplatin infusion.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age\>18 years treated for colorectal cancer in Digestive Oncology service Rangueil hospital * Initiation of intravenous oxaliplatin chemotherapy at 85 mg/m² on a bimonthly schedule. * Ability to understand and answer a self-questionnaire. * Life expectancy egal or over 12 weeks * Signed informed consent form
Exclusion criteria
* Pre-existing motor and/or sensitive neuropathy. * Reflexology treatment within the last 6 months. * Contraindication to reflexology: venous thrombosis, trauma, wound or metastasis of the foot. * Patient covered by a legal protection scheme.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| number of sessions performed | 6 months | at least 50% of patients included and realized at least 70% of reflexology sessions over the 6-month treatment. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| concordance of peripheral neuropathy evaluation | every month until 6 months | peripheral neuropathy evaluation between physician's assessment and programming nurse's assessment |
Countries
France
Contacts
Primary ContactNadim FARES, MD
Outcome results
None listed