ARDS, Human, Nitric Oxyde
Conditions
Keywords
ARDS, Lung oedema, Capillary-alveolar permeability, Nitric Oxyde, Laser Spectroscopy
Brief summary
The aim of the study is to see if endogenous exhaled Nitric Oxyde (eNO) concentrations measured are significantly higher in ARDS patients admitted in ICU ; compared to control subjects in good health with no lung disease or global inflammation, operated under general anesthesia (i.e. intubated and ventilated) for thyroid or parathyroid.
Detailed description
The measurement of endogenous exhaled NO is monitored using a laser spectrometer machine connected to the expiratory circuit of the respirator. The measure is non-invasive and made by sampling expiratory gaz like for capnography. In control subjects, the measurement period corresponds to the first ten minutes after induction of anesthesia (with intubation) before surgical incision. In ARDS patients in intensive care, the measurement of eNO is made in the first twenty-four hours after intubation and ventilation of the patient with mechanical respirator. The primary endpoint is a significantly higher eNO concentration in patients suffering from Acute Respiratory Distress Syndrome (ARDS). Secondary endpoints will assess correlations between eNO concentrations and usual ARDS severity criteria: PaO2/FiO2; ventilator-free days; length of stay in intensive care and all-cause hospital mortality at 30 days.
Interventions
OTHERNon invasive measure of endogenous exhaled Nitric Oxyde in exhaled gaz, by a laser spectrometer
A sample of exhaled gases is taken from the expiratory part of the respirator circuit (same way as a capnometry measurement). A laser spectrometer continuously and non-invasively monitors online the concentrations of endogenous NO exhaled by patients.
Sponsors
University Hospital, Grenoble
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* For ARDS patients : * Patients with ARDS (according to the Berlin criteria) admitted in intensive care unit and intubated for less than 24 hours. * For control patients : * Patients with no major disease (classified 1 or 2 in the classification of the American Society of Anaesthesiology) * Patients undergoing general anaesthesia for a thyroïd or parathyroïd surgery
Exclusion criteria
* Minors under the age of 18 years old * Pregnant women * prisoners * patients who have withdrawn their consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Endogenous exhaled Nitric Oxyde (eNO) | Measurement of eNO over a period of 10 minutes just after induction of anesthesia | The primary endpoint is a significantly higher eNO concentration in ARDS patients. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Secondary endpoints will assess correlations between eNO concentrations and usual ARDS severity criteria | Measurement of eNO over a period of 10 minutes within the first 24 hours after intubation | ARDS severity criteria are: Partial arterial pressure of oxygen divided by inspired fraction of oxygen (PaO2/FiO2); ventilator-free days; length of stay in intensive care and all-cause hospital mortality at 30 days. |
Countries
France
Outcome results
None listed