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Lymphatic System Reflux After Lymphatic Operation

Influence of Lymphatic System Reflux After Operation in Patients With Lymphatic Disease

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06249360
Enrollment
79
Registered
2024-02-08
Start date
2023-09-01
Completion date
2023-12-30
Last updated
2024-02-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lymphedema

Brief summary

This study aimed to determine the impact on outcomes when recipient veins with reflux were used for LVA for the treatment of unilateral lower limb lymphedema.

Detailed description

The use of recipient veins with reflux for lymphaticovenous anastomosis (LVA) is discouraged because of the common belief that it may lead to venous-lymphatic reflux (VLR), a phenomenon in which venous blood is refluxed into the lymphatic lumen after anastomosis, which can lower the long-term patency rate. However, this concept has yet to be validated.

Interventions

OTHERVeins with reflux

This group included patients who used only recipient veins with reflux

OTHERReflux-free recipient veins

This group included patients who utilized only reflux-free recipient veins

Sponsors

Chang Gung Memorial Hospital
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
20 Years to 100 Years
Healthy volunteers
No

Inclusion criteria

* This study including patients diagnosed with lymphatic-related diseases at Kaohsiung Chang Gung Memorial Hospital from October 1, 2015, to December 31, 2022. * Patients who underwent LVA for unilateral lower-limb lymphedema.

Exclusion criteria

* Patients under the age of 20. * Patients lost to follow-up or with incomplete data.

Design outcomes

Primary

MeasureTime frameDescription
Volume change after LVA.6/12 monthsThe primary endpoint was the volume change at 6/12 months after LVA.

Countries

Taiwan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026