Intermittent Theta Burst Stimulation and Repetitive Transcranial Magnetic Stimulation Combined With Robotic Rehabilitation on Ambulation in Spinal Cord Injury Patients

Effect of Intermittent Theta Burst Stimulation and Repetitive Transcranial Magnetic Stimulation Combined With Robotic Rehabilitation on Ambulation and Lower Extremity Motor Function in Chronic Spinal Cord Injury Patients

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06248476

Enrollment

Registered

2024-02-08

Start date

2024-03-01

Completion date

2025-04-01

Last updated

2026-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spinal Cord Injuries

Keywords

Spinal cord injury, rTMS, iTBS, Ambulation, Lower extremity motor function

Brief summary

Comparison of different types of transcranial magnetic stimulation techniques which are intermittent theta burst stimulation (iTBS) and high frequency repetitive transcranial magnetic stimulation (rTMS) in patients with spinal cord injury

Detailed description

iTBS lasts shorter than rTMS so that this technique comfortable than rTMS for both patients and also physicians. Aim of this study is to compare effectiveness of this techniques. If results are same, iTBS can be used instead of rTMS.

Interventions

DEVICETranscranial Magnetic Stimulation

Transcranial magnetic stimulation is non-invasive stimulation technique which modifies cortical excitability through forming magnetic field

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 45 Years

Healthy volunteers

Inclusion criteria

* Incomplete spinal cord injury (ASIA C and D) * 12 months after spinal cord injury * At least 10 meters walking independent or with canadian, walker or walking stick * Put signature to approved form

Exclusion criteria

* Epileptic seizure * Pacemaker * Pregnancy * Neurological disease different from spinal cord injury * Metalic implant in brain or scalp * Brain surgery * Orthopedic problem in lower extremity * Malignity

Design outcomes

Primary

Measure	Time frame	Description
Lower extremity motor score	Before treatment (0. week), finishing time of treatment (2.week), 4 weeks after finishing time of treatment (6.week)	Assesment of lower extremity key motor muscle function according to American Spinal Injury Association

Secondary

Measure	Time frame	Description
Walking index for spinal cord injury II	Before treatment (0. week), finishing time of treatment (2.week), 4 weeks after finishing time of treatment (6.week)	Assesment of ambulation ability after spinal cord injury
Spinal cord injury independence measurement III (SCIM III)	Before treatment (0. week), finishing time of treatment (2.week), 4 weeks after finishing time of treatment (6.week)	Assesment of independence of daily living activities in patients with spinal cord injury
10 meter walking test	Before treatment (0. week), finishing time of treatment (2.week), 4 weeks after finishing time of treatment (6.week)	Patients with spinal cord injury walk between two markers, that distance is 10 meters
Time up and go test	Before treatment (0. week), finishing time of treatment (2.week), 4 weeks after finishing time of treatment (6.week)	Patients sit chair, then walk 3 meter, return and sit again
Motor evoked potential	Before treatment (0. week), finishing time of treatment (2.week), 4 weeks after finishing time of treatment (6.week)	For assesment of cortical excitability

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 12, 2026