In-hospital Mortality
Conditions
Brief summary
The present multicentre retrospective cohort study aimed to investigate the association between intraoperative administration of dexmedetomidine and postoperative mortality in hospitals. The investigators set out to test the hypothesis that perioperative dexmedetomidine use, as an adjunct to general anesthesia, diminishes postoperative mortality in hospitals across all categories of surgical patients.
Interventions
DRUGDexmedetomidine
whether intraoperative dexmedetomidine was administered adjunct to propofol for patients undergoing surgeries under general anaesthesia
Sponsors
The Affiliated Hospital of Qingdao University
First Hospital of China Medical University
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Sir Run Run Shaw Hospital
Xijing Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* adult patients (aged ≥18 years) * undergo general anaesthesia with propofol * from January 1, 2014 to June 30, 2018
Exclusion criteria
* patients undergoing intervention procedures under monitored anaesthesia care (MAC) * patients undergoing minor procedures under local or regional anaesthesia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| in-hospital all-cause mortality | from the time of end of surgery until time of documented hospital discharge or time of death, whichever came first, assessed up to 1 year | in-hospital deaths or discharged to hospice (or home) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| length of postoperative hospital stay | from the time of end of surgery until time of documented hospital discharge or time of death, whichever came first, assessed up to 1 year | in days |
| admission to the intensive care unit (ICU) | from the time of end of surgery until time of documented hospital discharge or time of death, whichever came first, assessed up to 1 year | unplanned admissions |
| adverse events after surgery | from the time of end of surgery until time of documented hospital discharge or time of death, whichever came first, assessed up to 1 year | severe stroke, the necessity for renal replacement therapy (RRT), myocardial infarction, ventilator-associated pneumonia (VAP), acute respiratory distress syndrome (ARDS), unplanned reoperation due to postoperative complications, sepsis, and multi-organ dysfunctions (MODs), if any |
Outcome results
None listed