Endocytoscopy of Upper Gastrointestinal Tract in Acute Graft-versus-host Disease: a Pilot Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06247891

Enrollment

Registered

2024-02-08

Start date

2021-08-01

Completion date

2025-05-31

Last updated

2026-06-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endocytoscopy

Keywords

Endocytoscopy, acute graft-versus-host disease

Brief summary

The goal of this clinical trial is to test the assess the diagnostic effectiveness of endocytoscopy in patients with underlying UGI aGvHD. The main question it aims to answer is: the effectiveness of ECS for diagnosing UGI aGvHD. Participants will undergo endoscopy, endocytoscopic evaluation and biopsy simultaneously. If there is a comparison group: Researchers will compare endoscopic, endocytoscopic and pathologic findings of these patients.

Interventions

PROCEDUREECS Group

Patients underwent endoscopic and endocytoscopic evaluations.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

14 Years to No maximum

Healthy volunteers

Inclusion criteria

* aged ≥ 14 years * developed UGI symptoms within first three months after engraftment or during the tapering of immunosuppressive agents

Exclusion criteria

* \< 14 year * with underlying gastrointestinal disease before allo-HSCT * incomplete medical information

Design outcomes

Primary

Measure	Time frame	Description
the effectiveness of endocytoscopy for diagnosing UGI aGvHD	three months	the percentage of esophageal, gastric, and duodenal UGI aGvHD diagnosed by endocytoscopy

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 26, 2026