Hepatocellular Carcinoma, Hyperthermic Intraperitoneal Chemotherapy, Ruptured Liver
Conditions
Keywords
ruptured and bleeding of Hepatocellular carcinoma, Hyperthermic intraperitoneal chemotherapy, recurrence-free survival
Brief summary
Patients with ruptured liver cancer and bleeding after surgical resection were included according to the criteria of admission, and the patients were divided into experimental and control groups. the primary efficacy end point was RFS, and the secondary end point was the rate of abdominal implant metastases and OS.To analyze the efficacy of HIPEC.
Detailed description
Patients with ruptured liver cancer and bleeding after surgical resection were included according to the criteria of admission, and the patients were divided into groups: experimental group: surgical resection combined with intraperitoneal hyperthermic perfusion chemotherapy, and control group: simple surgical resection. At further follow-up, the primary efficacy end point was time to Recurrence free survival (RFS) ,the time from the patient's treatment until the discovery of abdominal metastases or until the follow-up period, and the secondary end point was the rate of abdominal implant metastases, that is, according to the postoperative follow-up test and imaging findings, the incidence of abdominal implantation and metastasis, until the end of abdominal recurrence or metastasis or observation period. Overall Survival OS and survival rate: the time from the time the patient underwent partial hepatectomy until death from tumor causes or the end of the observation period. To analyze the efficacy of HIPEC.
Interventions
PROCEDUREintraperitoneal hyperthermic perfusion chemotherapy
（1）Partial hepatectomy: The reasonable resection method was selected according to the tumor location, residual liver volume and the operation process. The tumor margin should be more than 1 cm, the abdominal cavity was flushed with sterile warm distilled water. In the control group,1-2 abdominal drainage tubes were placed on the hepatic cross-section, in the exposed group,4 abdominal perfusion tubes were placed in the right hepatic apex, splenic fossa, left and right pelvic cavity to perform HIPEC postoperatively. (2) HIPEC: Temperature setting:43 °C perfusion time:60 min, perfusion speed:400-600 mL/min ,perfusion volume:3000 mL. （3）Hepatic artery embolization：Through the common femoral artery, the catheter passed through the abdominal aorta, celiac trunk, the common hepatic artery and the inherent hepatic artery to the blood supply target artery of liver cancer. The embolic agent Lipiodol was mixed and injected to embolize the bleeding artery to stop bleeding.
Sponsors
Zhujiang Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. according to the clinical diagnostic criteria of primary liver cancer (2022 edition) or confirmed by pathology/cytology; 2. preoperative diagnosis of rupture and hemorrhage of liver cancer by clinical manifestation, examination and imaging; 3. Age 18-80 years; 4. Child-pugh class A or class B after liver protection and albumin correction, without severe heart, lung or renal dysfunction, without absolute contraindication to surgery; 5. ECOG-PS score of 0-1; 6. without other neoplastic diseases; 7. Sign and perfect the informed consent form before operation; 8. without postoperative liver failure, without major complications such as massive hemorrhage, purulent infection and multiple organ failure, and without discharge from hospital.
Exclusion criteria
1. having other active malignant tumor; 2. the expected survival time is less than 3 months; 3. Child-pugh class C, complicated with severe organic disease of important organs, complicated with severe cirrhosis.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intra-abdominal recurrence-free survival (RFS) | the time from surgical resection in patients with HCC until the detection of intra-abdominal recurrence or metastasis or the end of the observation period(2 years) | Intra-abdominal recurrence-free survival (RFS):the time from surgical resection patients with HCC until the detection of intra-abdominal recurrence or metastasis or the end of the observation period, based on postoperative follow-up test criteria and imaging findings(2 years) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Overall Survival (OS) | time from partial hepatectomy for HCC until death from any cause or end of observation period(2 years) | Overall Survival (OS): time from partial hepatectomy for HCC until death from any cause or end of observation period(2 years) |
| survival rate | time from partial hepatectomy for HCC until death from any cause or end of observation period | defined as 1-month,3-month,6-month, 1-year,2-year survival rate |
Contacts
Primary ContactMingxin Pan, Prof.
Outcome results
None listed