Acupuncture, Electroacupuncture, Periodontal Diseases, Periodontal Inflammation, Periodontal Pocket, Periodontitis
Conditions
Keywords
periodontitis, Acupuncture, Electroacupuncture, IL-6, IL-10, TNF-α, Cytokine, non-surgical periodontal therapy
Brief summary
The aim of this randomized, single-masked, controlled clinical trial study was to determine if the administration of electro acupuncture improves the outcomes obtained in combination with non-surgical periodontal therapy. Participants will get non-surgical periodontal therap with/without electro acupuncture. Researchers will compare EA and control groups to see if there is any relationship between acupuncture application clinical periodontal parameters,serum and saliva cytokine levels.
Detailed description
Periodontitis is a prevalent complex chronic inflammatory oral disease that can result in the progressive destruction of tooth supporting tissues and eventual loss of teeth. Although pathogenic bacteria are the triggers and provokers of periodontal inflammation, the main determinant of the destruction is the host immunoinflammatory response. The host response is modified by many genetic and environmental factors as well as various systemic diseases. Electroacupuncture (EA) has effects on both the immune system and inflammatory processes. The effect of acupuncture on the regulation of cytokine production has been mentioned in the literature. . No study has been found in the literature about the effects of EA on the host modulation in periodontitis patients. In this study, the investigators aimed to examine the effect of electroacupuncture application on the host modulation at periodontitis.
Interventions
PROCEDUREElectroacupuncture
LI-4, LI-11, GV-14, GV-20 acupuncture points were needled bilaterally.
Sponsors
Ataturk University
The Scientific and Technological Research Council of Turkey
Didem OZKAL EMINOGLU
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* absence of any systemic disease, * pregnancy or breast feeding; * not receiving anti-inflammatory drug therapy in the last 6 months, chemotherapy or radiotherapy;
Exclusion criteria
* Having a systemic disease such as cardiovascular, diabetes, hypertension, thyroid organ pathologies, chronic kidney failure * pregnant/breastfeeding * medication for any reason * smoker/tobacco user * other periodontal disease other than periodontitis * chronic inflammatory disease (COPD, asthma)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical periodontal parameters / clinical attachment level (CAL) | Baseline-week 3 | CAL was measured as the distance between the deepest point of the sulcus and the cemento-enamel junction |
| Clinical periodontal parameters / probing pocket depth (PPD) | Baseline-week 3 | PPD was measured as the distance between the deepest point of the sulcus and the gingival margin |
| Clinical periodontal parameters / bleeding on probing (BOP) | Baseline-week 3 | The presence of bleeding on probing is considered an objective sign of periodontal inflammation |
| Clinical periodontal parameters / plaque index (PI) | Baseline-week 3 | The amount of plaque present on the teeth was assessed using a plaque staining agent and graded according to the plaque index system |
| Clinical periodontal parameters / gingival index (GI) | Baseline-week 3 | The presence and extent of gingival inflammation and bleeding were graded according to the gingival index system |
| Biochemical findings | Baseline-day 7-week 3 | IL-6, IL-10, TNF-α |
Countries
Turkey (Türkiye)
Outcome results
None listed