Inflammation Markers in Hyperemesis Gravidarum

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06245811

Enrollment

215

Registered

2024-02-07

Start date

2022-01-20

Completion date

2022-06-20

Last updated

2024-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hyperemesis Gravidarum

Keywords

Hyperemesis gravidarum, Platelet criterion (PCT), Hemoglobin/red cell distribution width ratio (HRR), Neutrophil/lymphocyte ratio (NLR)

Brief summary

In this study, the relationship between the severity of hyperemesis gravidarum (HEG) disease and subclinical inflammatory factors such as Platelet Crit (PCT), Hemoglobin/red cell distribution width ratio (HRR), Neutrophil/lymphocyte ratio (NLR), was investigated.

Detailed description

A total of 215 pregnant women, 102 with hyperemesis gravidarum and 113 healthy pregnant women, were included in the study. HEG patients were divided into three groups according to the modified PUQE classification: mild (n=38), moderate (n=32) and severe (n=32). In our study, we proposed using a new prognostic marker for HEG patients. We think that our study will be a source for future studies on HEG.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 45 Years

Inclusion criteria

* Healthy pregnant women over 18 years of age * 5-16 weeks of gestation.

Exclusion criteria

Smoking, urinary tract infections, previously diagnosed psychological disorders, gastrointestinal disorders, multiple pregnancies, eating disorders, thyroid disorders, inflammatory disease, pregnancy with assisted fertilization technique.

Design outcomes

Primary

Measure	Time frame	Description
The Pregnancy Unique Quantification of Emesis/Stomach scoring system	2 months	1: Weight loss of 5% or more since the beginning of pregnancy 2: Vomiting at least three times a day 3: A ketonuria value of +1 or higher on a urinalysis test

Secondary

Measure	Time frame	Description
Body mass index	2 months	(BMI) (kg/m2) was obtained by dividing body weight (kg) by height (m2) squared

Countries

Turkey (Türkiye)

Outcome results