Pain, Postoperative
Conditions
Keywords
total knee arthroplasty, intraosseous infiltration
Brief summary
In patients with osteoarthritis of the knee whose pain cannot be relieved by conservative treatment, total knee arthroplasty (TKA) is the operation that increases the quality of life for the patient. Pain management after total knee arthroplasty TKA is an important consideration to improve patient outcomes and reduce length of stay. Periarticular injections of the knee are one of the techniques used to reduce pain after surgery. Studies have shown that compared to other methods of pain relief, they are effective and safe. At present, no studies to compare between multimodal intraosseous femoral injection & multimodal intraosseous tibial injection in Simultaneous Bilateral TKA patients.
Interventions
DRUGMultimodal Intraosseous Femoral Injection
Intraosseous injection of Ketorolac 15mg and Tranexamic acid 500mg in femoral canal
DRUGMultimodal Intraosseous Tibial Injection
Intraosseous injection of Ketorolac 15mg and Tranexamic acid 500mg in tibial canal
Sponsors
Department of Medical Services Ministry of Public Health of Thailand
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
55 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients who will undergo bilateral Total knee Replacement due to osteoarthritis of both knees * Used of a cemented, PS design TKA surgery. * Able to give informed consent
Exclusion criteria
* Revision TKA * History of previous knee or hip surgery * History of allergic reaction or side effects to the drug that will be used in the experiment * Underlying diseases of chronic kidney disease or chronic liver disease (Child Pugh B or C) * Pregnancy * History of coagulopathy or abnormal blood coagulation profile(INR \>1.4 or aPTT ratio \> 1.4) * History of platelet dysfunction or platelet count \< 140,0000/mm3 * History of Thromboembolism * Use of Anticoagulants.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain score (Visual analog scale) | at 12 hours, 24 hours, 48 hours and 2 weeks after surgery | Visual analog scale (VAS) score from 0-10(0 was no pain, 10 was worst pain ) between multimodal intraosseous femoral injection & multimodal intraosseous tibial injection |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Post operative blood loss | intraoperative and up to 48 hours postoperatively (include intraoperative and drain) | — |
| Knee and Osteoarthritis Outcome Score (KOOS) | post operative 2 weeks | minimum and maximum values(0-100), higher scores mean a better outcome. |
| Amount of painkillers used | up to 24 hours after surgery | — |
| Side effects and complications | intraoperative to post operative 2weeks | — |
| Length of hospital stay | Admit to discharge date (up to 7 days) | Length of hospital stay record in number of days |
| knee range of motion | post operative 2 weeks | — |
Countries
Thailand
Contacts
Primary ContactThakrit Chompoosang, MD
Backup ContactTanahem Wijit, MD
Outcome results
None listed