Choroidal Neovascularization
Conditions
Brief summary
Choroidal neovascularization (CNV), also known as subretinal neovascularization, is a proliferative change from choroidal capillaries that has become one of the most important causes of blindness worldwide. CNV can occur in a variety of fundus diseases, including pathologic myopia, polypoidal choroidal vasculopathy. At present, intravitreal injection of anti-vascular endothelial growth factor (VEGF) drugs is the first-line effective treatment for CNV. Although a number of clinical studies have shown that the treatment of CNV with anti-VEGF drugs has achieved good visual and anatomical effects, there are still some patients whose CNV has not decreased significantly or even progressed continuously after treatment. Rapid advances in imaging technology have made it possible to explore the quantitative and qualitative characteristics of choroid and CNV, especially swept source optical coherence tomography angiography (SS-OCTA). The objectives are to improve the OCTA typing of CNV and analyze the vascular morphological characteristics of each type; to identify the changes in vascular characteristics of CNV after anti-VEGF treatment in vitreous cavity; and to elucidate the predictive effects of neovascularization and choroidal vascular characteristics on visual acuity and anatomic effects of vitreous anti-VEGF drug treatment for CNV.
Interventions
Intravitreal injection of anti- vascular endothelial growth factor (VEGF) treatment
Sponsors
Beijing Hospital
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Inclusion criteria
* Age \>18 years old * Active choroidal neovascularization (activity criteria: blood vessel leakage confirmed by FFA, or subretinal fluid accumulation or bleeding seen by OCT) * History of anti-VEGF drug therapy * At least 3 months of follow-up data.
Exclusion criteria
* Unable to complete the examination due to severe cataract or vitreous hemorrhage * Any retinal diseases except choroidal neovascularization, such as multifocal choroiditis, diabetic retinopathy * History of intraocular surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| choroidal thickness | 3 months | central choroidal thickness measured by SS-OCTA |
| Central retinal thickness | 3 months | central retinal thickness changes measured by SS-OCTA |
| Best-corrected visual acuity | 3 months | Best-corrected visual acuity changes from baseline to 3 months |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| choroidal vascularity index | 3 months | the ratio of vascular area to the total choroidal area measured by SS-OCTA |
Outcome results
None listed