Nocturnal Enuresis
Conditions
Keywords
Nocturnal enuresis, Vitamin D
Brief summary
We are group of researchers interested in causes and management of nocturnal enuresis, we embarked on this research on 2020 and we reached promising results regarding the role of vitamin D serum level in etiology and management of monosymptomatic enuresis.
Detailed description
this research was conducted as a comparative study regarding serum vitamin D levels in monosymptomatic enuretic and non enuretic children, also we compared urine osmolality and nocturnal polyuria in both groups and we found that low vitamin D levels are correlated with low nocturnal urine osmolality and increased incidence of nocturnal polyuria
Interventions
DIAGNOSTIC_TESTserum vitamin D
blood sample for serum vitamin D level Vitamin D serum level was measures using the ELISA technique. The Cal Biotech Vitamin D Kit (Mannheim, Germany) was used, which is a solid phase enzyme linked immunoassay (ELISA), based on the principal of competitive binding. Vitamin D deficiency was defined as serum Vit. D below 20 ng/ml.
DIAGNOSTIC_TESTurine osmolality
nocturnal urine osmolality: Clear instructions for mothers were to let the child void before sleep and every two hours till 8 am. Short intervals were meant to avoid enuretic episodes during calculation of nocturnal urine volume, and if occurred it mandates the repeat of chart on another day. Nocturnal urine collected over the night was tested for osmolality, it was measured in mOsm/kg.
volume and frequency from time of sleep till 8 am
Sponsors
Ain Shams University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
5 Years to 15 Years
Inclusion criteria
* Patients with PMNE. * which was defined as bedwetting frequency of 3 or more nights per week for at least 2 weeks of observation. * Didn't receive any previous treatment for enuresis.
Exclusion criteria
* Patients with non-monosymptomatic enuresis (associated with storage and/or voiding symptoms). -Patients with anatomical abnormalities (Meatal stenosis, Hypospadias, Epispadias, etc.). * Patients with neurological diseases. * Patients with Renal impairment. * Patient with previous pelvic, urological or brain and spinal cord surgery. * Patients with chronic constipation and irritable bowel habits. * Patients with active urinary tract infection. * Patients who are on vitamin D supplements.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Vitamin D level | through study completion, average 1 year. | low vitamin d levels in enuretic group |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| nocturnal polyuria | through study completion, average 1 year. | frequency volume chart idobtained |
| low nocturnal urine osmolality | through study completion, average 1 year. | nocturnal urine osmolality |
Countries
Egypt
Outcome results
None listed