Epilepsy, Parkinson Disease
Conditions
Keywords
Focal seizure, Parkinson disease, Hyperkinetic seizures, Hypokinetic disorders, Dyskinesia, Networks, Basal ganglia
Brief summary
The expression of hypokinetic and hyperkinetic motor symptoms is accompanied by pathological synchronous oscillations of neuronal activity in this cortico-subcortical network with a wide frequency range. The purpose of this research is to study cortico-subcortical oscillations and their synchronization in two pathologies emblematic of hypokinetic (Parkinson's disease) and hyperkinetic (epilepsies) phenomena using a simple motor task and comparing different situations.
Detailed description
In order to define the link between the characteristics of the oscillations (frequency, amplitude, phase relation) within this cortico-subcortical network and movement (normal or pathological) in humans, a simple motor task of gripping/pulling a lever has been designed. The local field potentials (LFPs) will be collected during the same motor task in : i) patients with Parkinson's disease, using a high-resolution electroencephalogram (EEG) and the PERCEPT(TM) system (Medtronic) equipped with a sensing function for deep LFP recordings and in EEG-HR (for high resolution) for cortical recordings ii) patients with focal drug-resistant epilepsy, during a pre-surgical assessment by stereo-electro-encephalography (SEEG). The SEEG allows the recording of both the cortex and the subcortical regions in a concomitant manner, and a direct correlation can be studied.
Interventions
PROCEDUREHigh Resolution Electroencephalogram (EEG-HR)
Local field potentials (LFP) recording using EEG-HR
PROCEDUREStereo-electro-encephalography (SEEG)
Local field potentials (LFP) recording using sEEG
Sponsors
University Hospital, Bordeaux
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
: * Male or Female * Between 18 and 75 years of age * With Parkinson's disease and already operated with implantation of electrodes in the Subthalamic nucleus connected to a PERCEPT (TM) device. * Giving free, informed, written consent signed by the participant and the investigator Or * With drug-resistant epilepsy and benefiting from a phase II pre-surgical assessment with intracerebral electrophysiological exploration by stereo-EEG * With at least one electrode exploring the basal ganglia or the thalamus. * Able to perform the simple motor task * Affiliated or beneficiary of a social security scheme; * Giving free, informed, written consent signed by the participant and the investigator
Exclusion criteria
* Be incapable of giving consent personally * Be subject to a legal protection measure or be placed under judicial protection; * Being pregnant or breastfeeding * Present a serious and/or decompensated somatic or psychiatric illness
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| difference in the cortico-subcortical electrophysiological coherence value | Day 1 | difference in the cortico-subcortical electrophysiological coherence value between normal movement (control condition) and hypo- or hyperkinetic pathological movement |
Countries
France
Contacts
Primary ContactJérôme AUPY, Docteur
Outcome results
None listed