Glaucoma, Open-Angle
Conditions
Brief summary
The investigators will test the hypothesis that images of the optic nerve head taken a 2 different eye pressures will yield strain estimates that are predictive of the course of glaucoma.
Detailed description
Existing glaucoma patients and suitable control adults will be imaged with an FDA-approved optical coherence tomography instrument. Those who are imaged at 2 different eye pressures will generate biomechanical strain estimates. These will be compared to visual field and retinal nerve fiber layer measurements over time. The investigators expect that baseline strain and their changes over time will be associated with progression rate of glaucoma damage, providing a biomarker for susceptibility.
Interventions
DEVICEImages of eye at 2 eye pressures
subject images of the eye's optic nerve head are studied
Sponsors
Johns Hopkins University
National Eye Institute (NEI)
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* Existing glaucoma patients of Johns Hopkins
Exclusion criteria
* Inability to perform imaging * illiterate * hearing impaired * non-English speakers
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Optic nerve head mechanical strain compared to visual field change over time | Approximately 3 years | Strains measured at baseline are tested for association with glaucoma course |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORHarry Quigley
Johns Hopkins School of Medicine
Outcome results
None listed