Lymphedema
Conditions
Brief summary
The project aims to compare the differences in the expression of cell death through apoptosis and iron-dependent cell death after the reduction of edema symptoms following lymphedema surgery in patients.
Detailed description
This project aims to investigate the expression of cell death through apoptosis and iron-dependent cell death in the subcutaneous adipose tissue of patients with lymphedema. The study also seeks to explore the roles of these processes among lymphatic endothelial cells, adipocytes, and macrophages, and their association with lymphedema, thus gaining insights into the pathophysiological mechanisms of lymphedema. Furthermore, the project aims to compare the differences in the expression of cell death through apoptosis and iron-dependent cell death after the reduction of edema symptoms following lymphedema surgery in patients.
Interventions
OTHERPatients underwent lymphedema surgery
Patients who have developed lymphedema and undergone lymphedema surgery.
OTHERPatients underwent surgery without LVA
For patients who have not experienced lymphedema but require surgery due to other disease such as cancer, trauma, chronic wounds, skin defects, etc.
Sponsors
Chang Gung Memorial Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* Control Group: Patients who have not experienced lymphedema but require surgery due to other diseases such as cancer, trauma, chronic wounds, skin defects, etc. * Experimental Group: Patients who have lymphedema and undergone lymphedema surgery.
Exclusion criteria
* 1\. Individuals with venous thrombosis, chronic heart failure, and renal failure. * 2\. Vulnerable populations, individuals with limited mobility, pregnant women, and minors. * 3\. Those expected to be unable to attend follow-up visits or complete the study smoothly. * 4\. Participants who express doubts about the trial and cannot provide satisfactory answers.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The correlation between post-LVA volume reduction | 1 month after surgery | The differences in expression of cell necrosis and iron-dependent cell death after lymphedema surgery were observed in patients, following alleviation of edema symptoms. |
Countries
Taiwan
Contacts
Primary ContactChing-Hua Hsieh, PhD
Outcome results
None listed