Postoperative Pain, Postpartum Depression
Conditions
Keywords
midazolam with low dose ketamine, low dose ketamine, postoperatıve analgesıc need, postpartum depression
Brief summary
The results of ketamine, ketamine and midazolom and placebo can be copied after birth in cesareans subjected to spinal anesthesia.
Detailed description
Postpartum depression will be evaluated by dividing the patients into 3 groups: group 1 as ketamine, group 2 as ketamine and midasom, and group 3 as placebo group.
Interventions
DRUGApplication of ketamine and midazolam or ketamine alone to patients undergoing cesarean section under spinal anesthesia
A single dose of 0.5 mg/kg IV diluted to 5 ml with 0.9% saline was planned to be administered simultaneously to the Ketamine Group (GROUP 1), ketamine and midazolam within 5 minutes after the newborn umbilical cord was clamped (Group 2). After midazolam 0.03 mg/kg is given, a single dose IV bolus of 0.5 mg/kg diluted to 5 ml with 0.9% saline will be administered. Patients experience dizziness, hallucinations, nausea, headache, vomiting, diplopia and blurred vision, the time until the first analgesic request; Depression parameters will be evaluated with the Edinburgh Postpartum Depression Scale (EPDS) in all patients before cesarean section and at the 1st, 2nd and 4th weeks after birth.
Sponsors
Inonu University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
American Society of Anesthesiologists 2-.3 18 -45years old Patients planned to be born by cesarean section The patient requests a cesarean section with spinal anesthesia ExclusionCriteria: Pathological obstetric complications Hypertension Contraindication for ketamine Contraindication for spinal
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| postpartum depression | 4 weeks | Reducing postpartum depression with low-dose ketamine |
| intraoperative complications | 1 day | Reducing postpartum depression by reducing ketamine-related intraoperative complications |
| postoperative pain | 1 day | Reducing postoperative pain with low dose ketamine |
Countries
Turkey (Türkiye)
Contacts
Primary ContactDUYGU DEMIROZ, dr
Backup ContactOSMAN TOPLU, dr
Outcome results
None listed