Periodontal Diseases
Conditions
Keywords
8-isoprostane, adenosine deaminase, GCF
Brief summary
This study aims to assess the diagnostic potential of gingival crevicular fluid (GCF) biomarkers, specifically 8-iso Prostaglandin F2α (8-iso-PGF2α) and adenosine deaminase (ADA), in evaluating periodontal health and disease conditions.
Detailed description
Conducted as a single-blind, cross-sectional investigation, this study comprised 26 individuals categorized as periodontally healthy, 27 with gingivitis, and 27 diagnosed with periodontitis. The participant pool included individuals with various periodontal concerns who were referred to the Department of Periodontology Clinic at Kahramanmaraş Sütçü İmam University. The classification of periodontal health, gingivitis, and chronic periodontitis adhered to the 2018 criteria outlined by the European Federation of Periodontology
Interventions
DIAGNOSTIC_TEST8-iso Prostaglandin F2α and Adenosine Deaminase
We took gingival crevicular fluid samples from patients who applied to our clinic and evaluated the -iso Prostaglandin F2α and Adenosine Deaminase levels in the samples.
Sponsors
Eda Cetin Ozdemir
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients having more than 20 teeth, minimum age 18, maximum age 65
Exclusion criteria
* Patients with systemic disease, Active smokers, Pregnant women, individuals with a history of orthodontic treatment, or those who had undergone periodontal treatment, regardless of whether it was surgical or non-surgical (within the last one year),
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in 8-iso Prostaglandin F2α and Adenosine Deaminase scores in periodontal disease | 2023 | We expect 8-iso Prostaglandin F2α and Adenosine Deaminase scores to increase in periodontal disease. |
Countries
Turkey (Türkiye)
Outcome results
None listed