Pain
Conditions
Brief summary
This research program aims to investigate the influence of paracetamol on blood pressure and the cyclooxygenase (COX) - prostaglandine (PG) pathway in patients with pain. Through an observational pilot study, we will use advanced LC/ESI-MS/MS methodology to analyze the COX-OG pathway in plasma and urine. The study will assess the effects of paracetamol compared to ibuprofen, considering different types of pain. The primary focus is to understand the changes in blood pressure and the COX-PG pathway upon initiation or discontinuation of paracetamol, with safety analysis as a secondary consideration.
Interventions
OTHERroutine clinical treatment of pain with paracetamol or ibuprofen
No intervention beside clinical routine management
Sponsors
Charite University, Berlin, Germany
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Headache and orosurgical patients treated at the respective charite outpatient clinic. * Age 18 years or older * Able to consent * Patients with migraine type headache treated with paracetamol or ibuprofen within the last 12 hours or not treated with paracetamol or ibuprofen within the last 48 hours * Patients treated with with paracetamol or ibuprofen undergoing orosurgery for wisedome tooth extraction
Exclusion criteria
* Pregnancy * Arterial hypertension * Use of beta blockers * Use of COX inhibitors other than paracetamol or ibuprofen, including low-dose acetylsalicylic acid * Stable prophylactic therapy of migraine for less than 3 weeks * Use of tryptans in the last two days (Frovatriptane in the last 6 days) * Oral surgery patients using paracetamol or ibuprofen in the last 24 hours * Known allergy to paracetamol or ibuprofen
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prostanoid levels | just before treatment and 24 hours after treatment with paracetamol or ibuprofen | A comprehensive lipidomic analysis measuring the levels of prostanoids in plasma and spot urine samples using liquid chromatography tandem mass spectrometry (LC/ESI-MS/MS) technology in all participants. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Blood pressure | just before treatment and 24 hours after treatment with paracetamol or ibuprofen | Automated office and ambulatory blood pressure measurement |
Contacts
Primary ContactEngi Algharably, PhD
Outcome results
None listed