Cardiovascular Diseases, Kidney Transplant; Complications
Conditions
Keywords
Coronary artery disease, Kidney transplantation, Cardiovascular risk assessment, Heart disease, Chronic kidney disease
Brief summary
Cardiovascular disease (for example, heart attack, stroke, heart failure) is the commonest complication of kidney failure. Kidney transplantation reduces cardiovascular risk but cardiovascular disease remains the commonest cause of death in patients following transplantation. Current strategies to assess patient's cardiovascular risk prior to kidney transplantation do not identify those at highest risk and do not improve outcomes. This study will use a heart scan known as computed tomography coronary angiography (CTCA) to see whether this scan can identify patients at highest risk of future cardiovascular disease prior to transplantation. Studies have shown it is able to do this in patients with normal kidney function. The aim of this study is to develop CTCA as an effective tool to risk stratify patients prior to kidney transplantation.
Interventions
RADIATIONComputed tomography coronary angiography (CTCA)
Single CTCA scan prior to kidney transplantation
Sponsors
University of Edinburgh
Chief Scientist Office of the Scottish Government
University of Glasgow
NHS Lothian
NHS Greater Glasgow and Clyde
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
16 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Has kidney failure and is on the waitlist for a kidney transplant * Age 16 years and over * Able to give informed consent
Exclusion criteria
* Contraindication to CT scanning, including contrast allergy * Patients being considered for a simultaneous kidney-pancreas, kidney-liver and/or kidney-islet transplantation * Inability to give informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants who have either a myocardial infarction or cardiovascular death | From time of CTCA scan to 36- and 60-months follow-up | The first event of myocardial infarction or cardiovascular death |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants who have a fatal or non-fatal myocardial infarction | From time of CTCA scan to 36- and 60-months follow-up | The first event of myocardial infarction (MI). MI will be defined according to the 4th Universal Definition of Myocardial Infarction. |
| Number of participants who are hospitalised due to any cardiovascular event | From time of CTCA scan to 36- and 60-months follow-up | Hospital admission due to any cardiovascular event (including myocardial infarction, heart failure, stroke, or any other cardiovascular disease) |
| Number of participants who die (all-cause death) | From time of CTCA scan to 36- and 60-months follow-up | Death due to any cause |
| Number of participants who have a cardiovascular death | From time of CTCA scan to 36- and 60-months follow-up | Death due to a cardiovascular cause (including myocardial infarction, heart failure, stroke, or any other cardiovascular disease) |
Countries
United Kingdom
Contacts
CONTACTGavin B Chapman, MBChB
CONTACTNeeraj Dhaun, MBChB
PRINCIPAL_INVESTIGATORNeeraj Dhaun, MBChB
University of Edinburgh
Outcome results
None listed