Anemia, Child Development, Gestational Diabetes, Gestational Hypertension, Health Problems in Pregnancy, Mother-Infant Interaction, Obesity, Pregnancy Outcomes, Preterm Birth
Conditions
Brief summary
The PKUBC-WF is a prospective cohort study carried out in Weifang city of Shandong, China. The primary aim of this study is to investigate the short-term and long-term effects of pre-pregnant and prenatal exposure on maternal and child health. Data are collected regarding environmental, nutritional and lifestyle exposures as well as short-term and long-term health outcomes of mothers and their children from birth to before 18 years old. Biological samples including peripheral blood, urine, placenta, umbilical cord, cord blood, and faeces are also collected.
Detailed description
Maternal and child health is of great concern globally. Early life phase of a fetus and infant is a critical period for the development of health and disease in the whole life. Exposure of negative environmental, nutritional and lifestyle factors in pregnant women during this period can have adverse effects on fetal and infant. In addition, for mothers, complications during pregnancy could also have a negative effect on long-term health of mothers, such as diabetes, hypertension. Thus, the Peking University Birth Cohort in Weifang is primarily aimed to investigate the short-term and long-term effects of pre-pregnant and prenatal exposure on maternal and child health. Data are collected regarding environmental, nutritional and lifestyle exposures as well as short-term and long-term health outcomes of mothers, husbands and their children from birth to before 18 years old. Biological samples including peripheral blood, urine, placenta, umbilical cord, cord blood, and faeces samples are also collected.
Interventions
OTHERNo Interventions
No intervention This is an observational study without any intervention
Sponsors
National Natural Science Foundation of China
Peking University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Pregnant woman 1. Pregnant women, 6-13\^+6 gestational weeks 2. Resided in Weifang in the past half years and have no plan to move out after delivery 3. Pregnant women who plan to have antenatal care and delivery in Weifang maternal&Child Hospital. 4. Pregnant women who is willing to participate in this study with informed consent * Pregnant woman's husband 1. His wife was eligible for enrollment 2. He is the biological father of the child (his wife's current pregnancy) 3. Pregnant women's husband who is willing to participate in this study with informed consent * Offspring 4. Children born to pregnant women who met the inclusion criteria after enrolling in this study. 5\. Before the age of 8 years, his/her mother provided written informed consent. 6. After 8 years old, he/she agreed to continue this study and signed the informed consent.
Exclusion criteria
* Participants who cannot communicate normally.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Numbers and morbidity of participants with pregnancy complications | At delivery | Including gestational diabetes, gestational hypertension, anemia, and hypothyroidism during pregnancy |
| Numbers and morbidity of participants with adverse pregnancy outcomes | At delivery | Including preterm birth, low birth weight, macrosomia, abortion, stillbirth, and birth defects. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Early Child development | Age at 6 weeks, 6 months and 12 months | Measured by Ages&Stages Questionnaires (ASQ).There are 6 questions in each of 5 domains of development: communication, gross motor, fine motor, problem-solving skills, and adaptive skills. Each question is given a 10 (yes), 5 (sometimes), or 0 (not yet) score according to the parents' answers. The sum scores (range from 0 to 300) and scores for each domain (range from 0 to 60) are calculated. Chinese norms are available for each domain, and any domain screened \<2 SDs below the mean is considered a positive screening. A higher ASQ score means better development. |
| Incidence of diabetes mellitus in women | 6 weeks after delivery and 3 years after delivery | Measured by health professionals in clinic |
| Incidence of hypertension in women | 6 weeks after delivery and 3 years after delivery | Measured by health professionals in clinic |
| Incidence of child overweight and obesity | At birth and age at 6 weeks, 6 months, 12 months, 2 years, 3 years, 6 years, 9 years, 12 years, 15 years, and 17 years | Measured by health professionals in clinic |
| Weight in kilogram changes during childhood | At birth and age at 6 weeks, 6 months, 12 months, 2 years, 3 years, 6 years, 9 years, 12 years, 15 years, and 17 years | Measured by health professionals in clinic |
| Incidence of attention-deficit/hyperactivity disorder in children | Age at 6 years | Measured by The Child Behavior Checklist (CBC) scale |
| Incidence of anxiety in adolescents | Age at 9 years, 12 years, 15 years, and 17 years | Measured by Social Anxiety Scale for Adolescents (SAS-A) scale |
| Incidence of depression in adolescents | Age at 9 years, 12 years, 15 years, and 17 years | Measured by Beck Depression Inventory-II (BDI-II) scale |
| Incidence of autism spectrum disorder in children | Age at 2 years, 3 years | Measured by The Modified Checklist for Autism in Toddlers, Revised with Follow-Up (M-CHAT-R/F) and Autism Behavior Checklist (ABC) scales |
| Height in centimeter changes during childhood | At birth and age at 6 weeks, 6 months, 12 months, 2 years, 3 years, 6 years, 9 years, 12 years, 15 years, and 17 years | Measured by health professionals in clinic |
Countries
China
Contacts
Primary ContactHaijun Wang, Ph.D
Backup ContactJue Liu, Ph.D
Outcome results
None listed