Hepatocellular Carcinoma, Hepatocellular Carcinoma Recurrent
Conditions
Brief summary
The goal of this observational study is to investigate the effect of non-selective beta-blocker (NSBB) on the recurrence of hepatocellular carcinoma (HCC) following liver transplantation in patients who underwent liver transplantation (LT) for treating hepatocellular carcinoma. The main question\[s\] it aims to answer are: * Is the usage of non-selective beta-blocker associated with decreased recurrence of hepatocellular carcinoma following liver transplantation? * Is the usage of non-selective beta-blocker associated with all-cause mortality following liver transplantation? Researchers will compare the NSBB group, including patients who received non-selective beta-blocker therapy for at least 30 consecutive days within 3 months prior to liver transplantation more than 30 days prior, with the control group to to see if non-selective beta-blocker treatment is associated with decreased recurrence of hepatocellular carcinoma following liver transplantation.
Interventions
DRUGNon-Selective Beta-Adrenoreceptor Agonists for Systemic Use
Non-selective blocker including Propranolol, Carvedilol PO was prescribed
Sponsors
Korea Health Industry Development Institute
Asan Medical Center
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patients * Underwent liver transplantation for treating hepatocellular carcinoma * Between Jan. 2008 - May. 2022
Exclusion criteria
* Pediatric patients (Age under 18 years) * Re-transplantation * Multi-organ transplantation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Kaplan-Meier survival analysis of HCC recurrence at 5-year follow-up | Baseline and 5-year follow-up | HCC recurrence, which was diagnosed based on pathological or radiographic evidence of new lesions consistent with HCC, and recurrence-free survival was collected and compared using Kaplan-Meier survival analysis. |
| Multivariate Cox regression analysis of HCC recurrence at 5-year follow-up | Baseline and 5-year follow-up | Multivariate Cox regression analysis was performed to identify the risk factors for HCC recurrence. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Kaplan-Meier survival analysis of overall survival at 5-year follow-up | Baseline and 5-year follow-up | Overall survival was collected and compared using Kaplan-Meier survival analysis. |
| Multivariate Cox regression analysis of overall survival at 5-year follow-up | Baseline and 5-year follow-up | Multivariate Cox regression analysis was performed to identify the risk factors for overall mortality. |
Outcome results
None listed