Stroke, Tactile Perception
Conditions
Brief summary
Quantify the flow of a tactile signal from the stimulus at the finger at the peripheral nervous system (PNS), to the central nervous system (CNS), and to cognitive perception at the brain in young adults (Aim 1) and individuals with and without stroke (Aim 2).
Interventions
BEHAVIORALTactile stimulation
Tactile stimuli of differing magnitudes will be applied
Sponsors
Virginia Polytechnic Institute and State University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
-right-hand dominance for participants who are neurotypical For Aim 1: -age range of 18-23 For Aim 2: * participants who are neurotypical will be a similar age to the participants with stroke * participants who are neurotypical will have no musculoskeletal and neurological conditions * participants with stroke will have a single stroke incident resulting in a unilateral lesion (ischemic and hemorrhagic) * participants with stroke will be in the chronic phase (\>1 year from stroke onset) * participants with stroke will have an onset of stroke after the age of 18 * participants with stroke who meet the criteria of having the capacity to provide informed consent, regardless of aphasia
Exclusion criteria
* minors * pregnant women * prisoners * adults not capable of consenting on their own behalf. For Aim 2: * participants with stroke who have used antispastic injections in the past six months * participants with stroke who have a lesion in the brainstem and/or cerebellum * participants with stroke who have a stroke arising due to brain surgery * participants with stroke who have hemineglect
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Conscious detection threshold | 30 minutes during the first session of a one session protocol | The magnitude at which a force stimulus applied to the finger can be first consciously detected. Different force levels will be applied, and the participant will indicate which of these forces can be detected. The changes in force applied will be in the units of N. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Brain activation | 60 minutes during the first session of a one session protocol | The magnitude and regions of brain activated in response to differing levels of force stimuli will be captured using fMRI. The % signal change in the brain will be used to define the brain activation in response to each force stimulus level. |
Countries
United States
Contacts
CONTACTNetta Gurari, PhD
PRINCIPAL_INVESTIGATORNetta Gurari, PhD
Virginia Polytechnic Institute and State University
Outcome results
None listed