Colorectal Cancer, Peritoneal Metastases
Conditions
Keywords
Colorectal Cancer, Synchronous peritoneal metastasis, DNA ploidy, Stroma-tumor fraction, Nucleotyping
Brief summary
Heterogeneity concerning survival in synchronous peritoneal metastasis from patients with colorectal cancer exists, thereby further classification is urgently required. This study aimed to validate a PSN-AI model based on DNA ploidy, stroma-tumor fraction, and nucleotyping (PSN) for the prediction of survival of synchronous peritoneal metastasis from colorectal cancer.
Interventions
OTHERAnalyse pathologic slides
HE-stained whole slide images were used for the validation of the PSN-AI model.
Sponsors
Sixth Affiliated Hospital, Sun Yat-sen University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Inclusion criteria
* Histological proof of synchronous peritoneal metastases of a nonappendiceal colorectal adenocarcinoma. * Resectable disease determined by computed tomography (CT) and a peritoneal cancer index (PCI) of ≤20 at diagnostic laparoscopy or laparotomy; * No evidence of systemic (e.g. liver, lung) colorectal metastases within three months prior to enrolment; * Undergoing cytoreduction surgery for synchronous peritoneal metastasis from colorectal cancer.
Exclusion criteria
* Combined with other types of malignant tumors.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Overall survival | At least 1-year follow up | The time between the date of diagnosis and the date of death (due to any cause) or the date of last follow-up. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Progression-free survival | At least 1-year follow up | The time from diagnosis to the onset of disease progression. |
Countries
China
Contacts
Primary ContactQiyuan Qin, PhD
Outcome results
None listed