Vascular Lesion
Conditions
Brief summary
The goal of this clinical trial is to evaluate oxygenation in the colon in people with acquired vascular abnormalities in the proximal colon.
Detailed description
The etiology of acquired vascular abnormalities of the large bowel (i.e. angiodysplasia, AVM, hemangiomas of the cecum. etc.) are unknown. These lesions typical appear as ectatic, dilated, and tortuous blood vessels within the submucosa and mucosa of the GI tract. In some patients they are the cause of acute large volume bleeding or a slower chronic bleed that manifests as chronic iron deficiency anemia. These lesions are more common in older individuals and those with underlying cardiac, pulmonary, and renal disease. As such, it is hypothesized that these lesions may result from chronic hypoxia. This study aims to evaluate oxygenation of the colon in people with acquired vascular abnormalities in the proximal colon compared to healthy controls.
Interventions
OTHEROxygen saturation
Measure oxygen levels in 5 proximal colon mucosa locations.
Sponsors
University of Chicago
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SCREENING
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 89 Years
Healthy volunteers
Yes
Inclusion criteria
* Undergo standard of care colonoscopy * People with a history of vascular lesions of the colon * People with healthy colon * 18 - 89 years of age
Exclusion criteria
* Age \< 18 years * Age \> 90 years * People with ulcerations in at ascending colon opposite the ileocecal valve * Previous colon surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Quantitative analysis of colonic oxygen saturation levels | baseline-12 months | Colonic oxygen saturation levels will be compared between patients with vascular lesions of the colon and healthy controls. |
Countries
United States
Contacts
CONTACTJoel Pekow, MD
CONTACTKristi Kearney, RN
PRINCIPAL_INVESTIGATORJoel Pekow, MD
University of Chicago
Outcome results
None listed