Respiratory Distress Syndrome in Premature Infant
Conditions
Brief summary
The purpose of this study is to evaluate the benefits and safety of Intrapulmonary Percussive Ventilation in preterm infants. IPV has been demonstrated to be safe, and improve airway secretions clearance and decreased atelectasis in pediatric patients. We aim to evaluate the effects of IPV in preterm infants.
Interventions
IPV applied at increasing intervals, starting every 6 hours, and ending at every 24 hours, for a total of 7 days.
Sponsors
Augusta University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Application of Intrapulmonary Percussive Ventilation (IPV) in preterm neonates, older than 14 days, who require mechanical ventilation. IPV will be administered in increasing intervals, for 15 minutes, starting every 6 hours, and ending every 24 hours; for a total of 7 days.
Eligibility
Sex/Gender
ALL
Age
14 Days to No maximum
Healthy volunteers
No
Inclusion criteria
* Premature infants born before 32 weeks of gestation with birth weight less than 1500 grams. * Infants requiring positive pressure ventilation by 14 days of life.
Exclusion criteria
* Infants with known or suspected chromosomal anomalies (Trisomy 13, 18, 21) * Infants with Congenital Diaphragmatic Hernia * Presence of air leak syndrome (pneumothorax, pneumomediastinum) * Previous diagnosis of air leak syndrome.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mechanical ventilation and supplemental oxygen | From the date of starting treatment protocol to 2 weeks after. | Need for mechanical ventilation and supplemental oxygen administration |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Diagnosis of Bronchopulmonary Dysplasia | At 36 weeks gestational age | Need for mechanical ventilation and supplemental oxygen administration |
Outcome results
None listed