Cognition, Immunity
Conditions
Keywords
Mango, Immunity, cognition
Brief summary
The main objectives of our proposed study are to determine the effects of mango consumption on immune and cognitive functions in free-living college going young adults aged 18-30 years
Detailed description
The main objectives of our proposed study are to determine the effects of mango consumption on immune and cognitive functions in free-living college going young adults aged 18-30. To accomplish these objectives, a randomized controlled, parallel design study is proposed with two groups consuming their habitual diet, but with one (Mango group) receiving 1.5 servings of mango/day and the other (Control group) abstaining from eating any mango for the duration of the study.
Interventions
DIETARY_SUPPLEMENTMango group
Participants will consume 1.5 cups of mangos per day for 12 weeks.
Sponsors
Loma Linda University
National Mango Board
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Investigator, Outcomes Assessor)
Masking description
The investigator and outcome assessor will not be aware of which participant is in which arm
Intervention model description
this will be a12 week, parallel study , free living with college going young adults aged 18-30 years
Eligibility
Sex/Gender
ALL
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* Male and female college students aged 18-30 years
Exclusion criteria
* known intolerance or allergy to mangos * regular intake of mangos and/or fruits of a similar nutritional content such as peach, nectarine, papaya, apricot and cantaloupe * using cognition and/or immune-boosting supplements or vitamins * recent exposure to antibiotics and corticoids * uncontrolled chronic diseases and mental illnesses, clinical depression, and immunocompromised state
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in lymphocyte populations | baseline to 12 weeks | Immunophenotyping will be performed by flow cytometry to measure the number of T helper, T cytotoxic, Naive and memory cells and B cells |
| Changes in Lymphocyte activity | baseline to 12 weeks | The production of lymphocytes will be measured in the supernatant using enzyme linked immunosorbent assay (ELISA) |
| Changes in cytokine production | baseline to 12 weeks | The cytokines produced due to lymphocyte activity will be measured in the supernatant using enzyme linked immunosorbent assay (ELISA) |
| Changes in serum inflammatory cytokine concentration | baseline to 12 weeks | changes in the concentrations of the inflammatory cytokines will be performed on serum using enzyme linked immunoassay (ELISA) will include hs-CRP, interleukin (IL)-1B, IL-6, TNF a, IL-10, IL-2, IFN-γ, E-selectin, |
| changes from baseline in global cognitive composite score | baseline to 12 weeks | The composite score will be calculated using the scores from the tests listed below. Scores will be calculated with the standardized scores of each test as the score of each participant minus the group mean and divide by its standard deviation. The composite score is the mean of the standardized scores. the 5 tests are: Rey Auditory Verbal Learning Test (RAVLT), Brief Visuospatial Memory Test, Digit Span, FAS Word Fluency, Symbol Digit Modalities Test |
| Change in serum brain-derived neurotrophic factor (pg/mL) | baseline to 12 weeks | changes in serum brain-derived neurotrophic factor (pg/mL) assessed by ELISA |
Countries
United States
Contacts
CONTACTSujatha Rajaram, PhD
CONTACTAmandeep Wright, MPH
PRINCIPAL_INVESTIGATORSujatha Rajaram, PhD
Loma Linda University
Outcome results
None listed