Association Between EEG Changes and Hormonal Response to Tracheal Intubation and Surgical Stimulation

Evaluation of the Association Between Electroencephalographic Changes and Hormonal Response to Tracheal Intubation and Surgical Stimulation in Abdominal Surgery: a Prospective Observational Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06228729

Enrollment

Registered

2024-01-29

Start date

2025-04-01

Completion date

2025-11-21

Last updated

2026-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Abdominal Surgery, Electroencephalogram, Endotracheal Intubation, Surgical Incision

Brief summary

This study aims to prospectively evaluate the relationship between changes in EEG and hormonal responses induced by endotracheal intubation and surgical incision following general anesthesia.

Detailed description

This study aims to investigate the relationship between changes in EEG patterns and stress hormone levels in patients undergoing open abdominal surgery under general anesthesia when subjected to endotracheal intubation and surgical incision stimuli. Hormone measurements (cortisol, ACTH) are taken at four time points: before endotracheal intubation (T1), one minute after intubation (T2), and one minute after surgical incision (T3). The investigators evaluate the correlation between hormone levels (cortisol, ACTH) and EEG band power changes (alpha, beta, delta) before and after endotracheal intubation and surgical incision.

Interventions

PROCEDUREEndotracheal intubation

Inserting endotracheal tube into the trachea

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to 80 Years

Healthy volunteers

Inclusion criteria

* 1\) Patients scheduled to undergo open abdominal surgery under general anesthesia with endotracheal intubation. * 2\) Patients requiring invasive blood pressure monitoring during surgery

Exclusion criteria

* 1\) Patients transferred to the intensive care unit after surgery * 2\) Surgery duration of less than one hour * 3\) Patients with neurological underlying conditions * 4\) Patients on chronic use of psychotropic medications and opioid drugs * 5\) Emergency surgery

Design outcomes

Primary

Measure	Time frame
Association between band power changes in EEG and hormone respones caused by endotracheal intubation	from the start of anesthesia induction to one minute after endotracheal intubation

Secondary

Measure	Time frame
Association between band power changes in EEG and hormone respones caused by surgical incision	from the start of anesthesia induction to one minute after surgical incision

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026