CHRONIC LIVER DISEASE
Conditions
Keywords
Fluid buildup in the belly (ascites), Gallstones., Muscle loss.
Brief summary
4a. Primary To assess postoperative mortality at 30 and 90 days using the VOCAL PENN score 4b. Secondary To assess potential differences in prediction accuracy between VOCAL-Penn and MELD for 30 and 90-day mortality
Detailed description
For each patient and surgery,we will be collecting detailed pre-operative data regarding demographics (age, sex, body mass index, surgery category, comorbidities (diabetes mellitus, hypertension), and pertinent laboratory values (sodium, creatinine, total bilirubin, the international normalized ratio \[INR\], albumin, platelet count.) The etiology of liver disease will be classified. To ensure that laboratory data accurately reflected the pre-operative state, only those from within 30 days prior to surgery will be considered For each patient VOCAL PENN score, MELD score, and Mayo score will be calculated using an online calculator.
Interventions
PROCEDUREpatients with liver disease who undergoing surgery
For each patient and surgery, we will be collecting detailed pre-operative data regarding demographics (age, sex, body mass index, surgery category, comorbidities (diabetes mellitus, hypertension), and pertinent laboratory values (sodium, creatinine, total bilirubin, the international normalized ratio \[INR\], albumin, platelet count.) The etiology of liver disease will be classified. To ensure that laboratory data accurately reflected the pre-operative state, only those from within 30 days prior to surgery will be considered For each patient VOCAL PENN score, MELD score, and Mayo score will be calculated using an online calculator.
PROCEDUREpatients with liver disease who do not undergoing surgery
For each patient and surgery, we will be collecting detailed pre-operative data regarding demographics (age, sex, body mass index, surgery category, comorbidities (diabetes mellitus, hypertension), and pertinent laboratory values (sodium, creatinine, total bilirubin, the international normalized ratio \[INR\], albumin, platelet count.) The etiology of liver disease will be classified. To ensure that laboratory data accurately reflected the pre-operative state, only those from within 30 days prior to surgery will be considered For each patient VOCAL PENN score, MELD score, and Mayo score will be calculated using an online calculator.
Sponsors
Asian Institute of Gastroenterology, India
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients with established cirrhosis Patients who had not received liver transplantation and who underwent surgery of interest were included These surgery categories will be the same as those used in the original VOCAL-Penn derivation study and will include the open abdominal, laparoscopic abdominal, and abdominal wall.
Exclusion criteria
* Patients with insufficient pre-operative data to compute the VOCAL-Penn score, Mayo risk score, or MELD-Na score will be excluded. Patients undergoing liver surgeries Patients who received multiple surgeries Those who didn't give consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To assess postoperative mortality at 30 and 90 days using the VOCAL PENN score | 2 years | . For comparison between prediction scores receiver operative curves will be used. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| To assess potential differences in prediction accuracy between VOCAL-Penn and MELD for 30 and 90-day mortality | 2 years | For subgroup analysis comparison between groups independent sample T test will be used. used. |
Countries
India
Contacts
Primary ContactPRACHITI Gokhe
Backup ContactMAHESH SHETTY
Outcome results
None listed