High Blood Pressure
Conditions
Brief summary
The goal of this study is to establish a diagnostic accuracy of an immediate pressor response to oral salt (IPROS) to identify salt sensitivity of blood pressure (SSBP)
Detailed description
Participants are given dietary salt and their BP is measured every 10 minutes for 2 hours. IPROS is diagnosed with significant mean arterial pressure increase For SSBP, participants are put on high salt diet for a week and monitored and low salt week. The Mean arterial pressure difference between high salt and low salt is used to diagnose SSBP
Interventions
OTHERsalt
After ≥8 hr overnight fasting, participants will be required to ingest 780 mg of sodium (2 g salt) and BP measured every 10 minutes for 2 hours to determine IPROS. For SSBP, Participants are put on low salt (50 mmol Na/day) followed by seven days of high salt diet (250 mmol Na/day). Participants' mean arterial pressure (MAP) difference between low- and high-salt diet will be used to define salt sensitivity (MAP≥8 mmHg) and salt resistance (MAP≤5 mmHg).
Sponsors
Mulungushi University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Participants will be included if they are males or females, aged 18-65 years.
Exclusion criteria
* Kidney disease, Cardiovascular disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| SSBP | 2 weeks | Salt sensitivity status |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| IPROS | 2 hours | Immediate pressor response |
Countries
Zambia
Contacts
Primary ContactSepiso K Masenga, PhD
Outcome results
None listed