Attention Deficit and Hyperactivity Disorders
Conditions
Keywords
ADHD, probiotics, quantitative electroencephalogram
Brief summary
Probiotics are widely used as supplement for various neurodevelopmental disorders. The mechanism of their therapeutic potential lies in the gut-brain axis, a two-way communication pathway through the neuroendocrine system. In the past, there have been many experiments to study the possible efficacy of probiotics in patients with ADHD. Although some studies have shown that probiotics can improve ADHD symptoms, most studies have used behavioral rating scales to evaluate. As a result, it is susceptible to informant bias. Standardized attentional tests and quantitative electroencephalogram (qEEG) can provide more objective data and detect possible changes in brain networks. Such changes may precede behavioral phenotypes. Therefore, the purpose of this study is mainly to detect the therapeutic effect of multiple strains of probiotics in patients with attention deficit hyperactivity disorder by using standardized attention tests and quantified brain waves (qEEG).
Interventions
DIETARY_SUPPLEMENTmultiple-strain probiotics
Juice HA capsule which contains more than one strain of probiotics
Sponsors
Tsyr-Huey Mental Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
8 Years to 11 Years
Healthy volunteers
No
Inclusion criteria
A patient is eligible for the study if all of the followings apply: 1. 8-11 children diagnosed with ADHD by board certified pediatric psychiatrist according to DSM-5 (assessment tool using SNAP criteria, at least 6/9 symptoms of inattention and/or hyperactivity/impulsivity (≧2/3 on each severity scale) on parents' and teachers' observation) 2. On stable psychotropic mediations (i.e. no change in dose of methylphenidate or antipsychotics) for past 8 weeks
Exclusion criteria
Any patient meeting any of the
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The Swanson, Nolan and Pelham Chinese (SNAP) rating scales | every one month for 3 months | for behavioral symptoms of ADHD, the minimum and maximum values (0-78), higher scores mean a worse outcome |
| Conners' Continuous Performance Test 3rd Edition | pre- and post-intervention (3 months) | a task-oriented computerised assessment of attention-related problems in individuals aged 8 years and older |
| quantitative electroencephalogram | pre- and post-intervention (3 months) | measurement of brain wave patterns and coherence |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| adverse events | every one month for 3 months | any adverse events occurred during study |
Countries
Taiwan
Contacts
Primary ContactYU-SHIAN CHENG, MDPhD
Outcome results
None listed