Pediatric Brain Tumor
Conditions
Brief summary
Nuclear magnetic resonance imaging (NMR) is used in pediatric brain tumors for purposes of diagnosis, evaluation of response to treatments, and monitoring of patients in follow-up. Through conventional imaging techniques it remains difficult to differentiate tumor recurrence from pseudo-progression or other iatrogenic changes after radiotherapy or chemotherapy, but it remains a relevant and essential clinical need for patient management.
Interventions
DIAGNOSTIC_TEST11C-MET-PET/RMN
60 children and/or adolescents (≤18 years) with a diagnosis of brain tumor (medulloblastoma, other embryonal tumors or high-grade gliomas), who have followed the contemporary adjuvant therapy protocol of post-surgical chemo and radiotherapy and completed radiotherapy for at least 6 months will undergo a brain MET-PET/MRI.
Sponsors
IRCCS San Raffaele
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 18 Years
Inclusion criteria
* children and/or adolescents (≤18 years) diagnosed with brain tumor. * children who underwent the contemporary adjuvant therapy protocol of post-surgical chemo and radiotherapy.
Exclusion criteria
* patients \>18 years
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| MET-PET/brain MRI in children with brain tumor for diagnosis of brain tumor recurrence compared to therapy-induced changes. | 4 years | The role of MET-PET/MRI and radiogenomics could play in the follow-up management of children and adolescents with brain tumors and in ensuring timely intervention in case of tumor recurrence/progression. |
Countries
Italy
Contacts
Primary ContactArturo Chiti
Backup ContactAlessandra Maielli
Outcome results
None listed