Diabetes Mellitus, Type 2, Periodontitis
Conditions
Keywords
adipokines, diabetes mellitus, inflammation, periodontitis
Brief summary
The present study aimed to determine the effect of non-surgical periodontal treatment (NSPT) on serum and salivary adipokine and interleukin-1β levels in periodontitis patients with or without type 2 Diabetes Mellitus (T2DM).
Detailed description
The present study aimed to determine the effect of non-surgical periodontal treatment (NSPT) on serum and salivary adipokine and interleukin (IL)-1β levels in periodontitis patients with or without type 2 Diabetes Mellitus (T2DM). A total of 80 patients; 20 healthy, 20 T2DM with periodontitis (P), 20 T2DM periodontally healthy, 20 systemically healthy with P were included in this study. At baseline, serum and saliva samples were collected and the whole mouth clinical periodontal parameters were recorded. Periodontitis patients received NSPT in 4 sessions. Clinical parameters were re-measured and samples were re-collected at 1 and 3 months after treatment. Serum and salivary levels of adipokines and IL-1β were analyzed using a flow cytometry-based technique of Lumina® map™. Data were analyzed using appropriate statistical tests.
Interventions
PROCEDURENon-surgical periodontal treatment
Non-surgical periodontal treatment was performed in a quadrant-wise manner at 1-week intervals.
Sponsors
University of Turku
Marmara University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Diabetes mellitus should be diagnosed for ≥1 year and HbA1c level should be at least %6,5 * Periodontitis should be diagnosed for at least 4 teeth with probing depth ≥5 mm with bleeding on probing (BOP) and also radiographic alveolar bone loss should be presence * Presence of at least 15 teeth
Exclusion criteria
* Received antibiotic treatment in the previous 3 months * Smokers * Pregnancy and lactation * Received periodontal treatment in the previous 6 months * Presence of less than 15 teeth * Having major diabetic complications
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Serum and Salivary Resistin Levels (pg/ml) | Change between baseline, 1 and 3 months after non-surgical periodontal treatment | Serum and salivary resistin levels |
| Serum and saliva IL-1β levels (pg/ml) | Change baseline, 1 and 3 months after non-surgical periodontal treatment | Serum and salivary IL-1β levels |
| Serum and Salivary Visfatin Levels (pg/ml) | Change baseline, 1 and 3 months after non-surgical periodontal treatment | Serum and salivary visfatin levels |
| Serum and Salivary Leptin Levels (pg/ml) | Change baseline, 1 and 3 months after non-surgical periodontal treatment | Serum and salivary leptin levels |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| HbA1c ( %) | Change baseline, 1 and 3 months after non-surgical periodontal treatment | Glycated Hemoglobin Level % |
Other
| Measure | Time frame | Description |
|---|---|---|
| Probing Depth (mm) | Change baseline, 1 and 3 months after non-surgical periodontal treatment | probing depth measured from the gingival margin seldom corresponds to sulcus or pocket depth in mm. |
| Clinical Attachment Level (mm) | Change baseline, 1 and 3 months after non-surgical periodontal treatment | The estimated position of structures that support the tooth as measured with a periodontal probe in mm; provides an estimate of a tooth's stability and of loss of bone support. |
| Bleeding on Probing (%) | Change baseline, 1 and 3 months after non-surgical periodontal treatment | Percentage of bleeding sites. Bleeding on probing, often abbreviated BOP, is a sign of inflammation and indicates some sort of destruction and erosion to the lining of the sulcus or the ulceration of sulcular epithelium. The blood comes from lamina propria after the ulceration of the lining. |
| Gingival Index | Change baseline, 1 and 3 months after non-surgical periodontal treatment | A measure of periodontal disease based on the severity and location of the lesion. Values 0,1,2 and 3 can be taken. While 0 indicates the least value, 3 indicates the maximum value. |
| Plaque Index | Change baseline, 1 and 3 months after non-surgical periodontal treatment | The measurement of the state of oral hygiene by Silness-Löe plaque index is based on recording both soft debris and mineralized deposits on the following teeth. Values 0,1,2 and 3 can be taken. While 0 indicates the least value, 3 indicates the maximum value. |
Countries
Finland, Turkey (Türkiye)
Outcome results
None listed