Ascites Hepatic, Cirrhosis, Liver, Liver Failure
Conditions
Brief summary
The investigators aim to study the predictive value of presepsin in ascites in newly admitted patients with chronic liver failure.
Detailed description
Presepsin is a plasmatic cleaved fragment of CD14. CD14 is a toll like receptor who has the role to identify certain lipopolysaccharides on the surface of bacteria (aerobes and anaerobes), thus promoting an inflammatory response. A study of 153 patients with liver cirrhosis published by a team of investigators from Iasi, Romania, has proven an useful role of plasma presepsin in early diagnosis of infections in patients in acute on chronic liver failure. In addition, plasma presepsin has been proposed as an independent predictor of mortality in patients with decompensated liver cirrhosis, without concomitant bacterial infections. Question to be answered by this study The investigators aim to evaluate the predictive role of ascites presepsin in patients with chronic liver failure. Hypothesis Presepsin levels in ascites may have a prognostic role in patients with ascites and chronic liver failure.
Interventions
DIAGNOSTIC_TESTDetermination of presepsin levels in ascites
A diagnostic paracentesis will be performed and presepsin level will be determined in ascites.
Sponsors
Carol Davila University of Medicine and Pharmacy
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patient with ascites and chronic liver failure * no contraindications and technical possibility to perform diagnostic paracentesis * age above 18 years old * informed consent
Exclusion criteria
* contraindications to paracentesis or technical impossibility to perform paracentesis * absence of informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mortality at 6 months | 6 months | Number of who deceased during admission or during the 180 days after admission divided by the number of patients who were admitted. An analysis will be done to see if the presepsin levels are predictive for this event. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Spontaneous bacterial peritonitis (SBP) rate | 6 months | The number of patients diagnosed with SBP during admission divided by the total number of patients. An analysis will be done to see if the presepsin levels are predictive for this event. |
| Hepatic encephalopathy rate | 6 months | Number of patients diagnosed with hepatic encephalopathy during admission divided by the total number of patients. An analysis will be done to see if the presepsin levels are predictive for this event. |
| Any infection rate | 6 months | The number of patients diagnosed with any infection during admission divided by the total number of patients. An analysis will be done to see if the presepsin levels are predictive for this event. |
Countries
Romania
Contacts
Primary ContactMihai Ciocirlan
Outcome results
None listed